ID | JOS-bpb.33.1988 |
著者:名前 | |
著者:別形式 | Wonglertnirant, Nanthida / Todo, Hiroaki / Opanasopit, Praneet / Ngawhirunpat, Tanasait / Sugibayashi, Kenji |
著者:カナ | |
著者:所属 | Silpakorn University, Faculty of Pharmaceutical Sciences / J城西大学薬学部 / Silpakorn University, Faculty of Pharmaceutical Sciences / Silpakorn University, Faculty of Pharmaceutical Sciences / 城西大学薬学部 |
著者:所属(別形式) | Silpakorn University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Science / Silpakorn University, Faculty of Pharmaceutical Sciences / Silpakorn University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Science |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬学会 |
出版者:カナ | ニホンヤクガクカイ |
出版者:別名 | The Pharmaceutical Society of Japan |
NCID | AA10885497 |
冊子ISSN | 09186158 |
電子ISSN | 13475215 |
掲載誌名 | |
巻 | 33 |
号 | 12 |
刊行年月 | 2010-12 |
開始ページ | 1988 |
終了ページ | 1993 |
コンテンツ作成日 | 2010-09-17 |
コンテンツ登録日 | 2013-07-16 |
識別番号:DOI | info:doi/10.1248/bpb.33.1988 |
識別番号:DOI(リンク) | |
識別番号:その他 | JOI:JST.JSTAGE/bpb/33.1988 |
抄録 | The objective of the present study was to obtain information to develop an effective delivery device regarding a sophisticated hollow microneedle array-patch system. Thus, the potential of hollow microneedles was investigated for enhancing the transdermal delivery of hydrophilic large molecular compounds, and the effect of variable parameters on drug release behavior was determined from skin. Fluorescein isothiocyanate (FITC)-dextrans (4.3 kDa), FD-4, was used as the main model compound, and it was successfully loaded into the lower epidermis as well as the superficial dermis of the skin in hairless rats by a hollow microneedle. The higher the volume of FD-4 solution injected, the faster the FD-4 release rate from skin. In addition, release rate tended to increase when FD-4 was administered dividedly by multiple injections. These release profiles of FD-4 were expressed by Fick's law of diffusion. Furthermore, a combination of the formulation strategy and hollow microneedle-assisted delivery was useful for controlling the drug release rate from skin. Release profiles from drug-loaded skin were also compared by changing the molecular weights of model compounds. The larger molecular size of compounds caused a lower release rate from skin. These results suggest the utilization of hollow microneedle to enhance transdermal delivery of large molecular compounds and provide useful information for designing an effective hollow microneedle system. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
このアイテムを表示する:本文(pdf) | ( 633.2KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |