ID | JOS-j.bbr.2018.11.017 |
著者:名前 | |
著者:別形式 | Akimoto, Hayato / Oshima, Shinji / Sugiyama, Tomoaki / Negishi, Akio / Nemoto, Tadashi / Kobayashi, Daisuke |
著者:カナ | |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 産業技術総合研究所バイオメディカル研究部門 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / National Institute of Advanced Industrial Science andT echnology (AIST), Biomedical Research Institute / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | Amsterdam |
出版者 | Elsevier |
冊子ISSN | 01664328 |
電子ISSN | 18727549 |
掲載誌名 | |
巻 | 359 |
刊行年月 | 2019-02 |
開始ページ | 342 |
終了ページ | 352 |
コンテンツ作成日 | 2018-08-15 |
コンテンツ修正日 | 2018-11-12 |
コンテンツ登録日 | 2019-04-13 |
識別番号:DOI | info:doi/10.1016/j.bbr.2018.11.017 |
識別番号:DOI(リンク) | |
PubMed番号 | 30447240 |
抄録 | The ability to cope successfully with stress is known as ‘resilience’, and those with resilience are not prone to developing depression. One preclinical animal model for depression is the chronic mild stress (CMS) model. There are CMS-resilient (do not manifest anhedonia) and CMS-susceptible (manifest anhedonia) rats. This study aimed to investigate the differences in the profiles of hippocampal metabolites between susceptible and resilient rats, and to identify a biomarker that can distinguish the two. We divided stress-loaded rats into susceptible and resilient types based on their sucrose preference values. We then conducted brain-derived neurotrophic factor (BDNF) quantification and metabolomic analysis in the hippocampus. Compared to the controls, no significant differences were observed in the hippocampal BDNF levels of susceptible and resilient rats. However, the control rats were clearly distinguishable from the susceptible rats in terms of their brain metabolite profiles; the control rats were difficult to distinguish from the resilient rats. CMS model rats showed an increase in the levels of N-acetylaspartate and glutamate, and a decrease in the levels of aspartate and γ-aminobutyric acid in the hippocampus. Of the 12 metabolites measured in the present study, N-acetylaspartate was the only one that could differentiate the three types (control, susceptible, and resilient) of rats. Thus, brain metabolomic analyses can not only distinguish CMS model rats from control rats, but also indicate stress susceptibility. The variation in the levels of N-acetylaspartate in the hippocampus of control, resilient, and susceptible rats demonstrated that it could be a biomarker for stress susceptibility. |
キーワード | |
注記 | This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2018 The Authors. Published by Elsevier B.V. |
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