城西大学機関リポジトリJURADevelopment of a membrane impregnated with a poly(dimethylsiloxane)/poly(ethylene glycol) copolymer for a high-throughput screening of the permeability of drugs, cosmetics, and other chemicals across the human skin Original

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Development of a membrane impregnated with a poly(dimethylsiloxane)/poly(ethylene glycol) copolymer for a high-throughput screening of the permeability of drugs, cosmetics, and other chemicals across the human skin Original

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ID	JOS-j.ejps.2014.09.024
著者：名前	三木, 涼太郎/市塚, 靖菜/山田, 巧実/木村, 聡一郎/江川, 祐哉/関, 俊暢/從二, 和彦/上田, 秀雄/森本, 雍憲
著者：別形式	Miki, Ryotaro / Ichituka, Yasuna / Yamada, Takumi / Kimura, Soichiro / Egawa, Yuya / Seki, Toshinobu / Juni, Kazuhiko / Ueda, Hideo / Morimoto, Yasunori
著者：カナ	ミキ, リョウタロウ/イチツカ, ヤスナ/ヤマダ, タクミ/キムラ, ソウイチロウ/エガワ, ユウヤ/セキ, トシノブ/ジュウニ, カズヒコ/ウエダ, ヒデオ/モリモト, ヤスノリ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	author
出版者	Elsevier
NCID	AA11527142
冊子ISSN	09280987
電子ISSN	18790720
掲載誌名	European Journal of Pharmaceutical Sciences
巻	66
刊行年月	2015-01
開始ページ	41
終了ページ	49
コンテンツ作成日	2014-09-30
コンテンツ登録日	2014-11-19
識別番号：DOI	info:doi/10.1016/j.ejps.2014.09.024
識別番号：DOI（リンク）	http://dx.doi.org/10.1016/j.ejps.2014.09.024
抄録	We aimed to develop a high-throughput screening (HTS) system for preliminary predictions of human skin permeability by using an artificial membrane that can mimic the permeation behaviour of lipophilic and hydrophilic compounds across the human skin. In this study, we synthesized a copolymer containing poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEG) 6000 and impregnated it onto a supportive membrane filter to prepare a PDMS/PEG 6000 copolymer-impregnated membrane. In addition, we synthesized another polymer without PEG units and used it to prepare an impregnated membrane for determining the role of PEG 6000 units in the PDMS/PEG 6000 copolymer-impregnated membrane. The permeation characteristics of the impregnated membranes were evaluated on the basis of the permeability coefficients of 12 model compounds with different lipophilicities, by using a 2-chamber diffusion cell, and these permeability coefficients were compared with those across the human skin. We obtained a good correlation between the permeability coefficients across the PDMS/PEG 6000 copolymer-impregnated membrane and human skin. Further, we evaluated the permeation characteristics of a 96-well plate model of the PDMS/PEG 6000 copolymer by using 6 model compounds. We obtained an ideal correlation between the permeability coefficients across the PDMS/PEG 6000 copolymer using a 96-well plate and those across the human skin. Thus, the PDMS/PEG 6000 copolymer would be a good candidate for preliminary evaluation of the permeability of lipophilic and hydrophilic compounds across the human skin.
キーワード	Skin permeability/Skin alternative/High-throughput screening/Preliminary evaluation/Synthetic polymer/Transdermal delivery
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
このアイテムを表示する：本文(pdf)	( 449.1KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.ejps.2014.09.024

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