ID | JOS-prp2.439 |
著者:名前 | |
著者:別形式 | Akimoto, Hayato / Negishi, Akio / Oshima, Shinji / Okita, Mitsuyoshi / Numajiri, Sachihiko / Inoue, Naoko / Ohshima, Shigeru / Kobayashi, Daisuke |
著者:カナ | |
著者:所属 | 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬局 / 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬学部薬剤作用解析学研究室 / 城西大学薬学部薬剤作用解析学研究室 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Analytical Pharmaceutics and Informatics |
著者版フラグ | publisher |
出版地 | Hoboken |
出版者 | wiley |
電子ISSN | 20521707 |
掲載誌名 | |
巻 | 6 |
号 | 6 |
刊行年月 | 2018-11 |
開始ページ | 1 |
終了ページ | 9 |
コンテンツ作成日 | 2018-07-25 |
コンテンツ修正日 | 2018-10-02 |
コンテンツ登録日 | 2019-02-15 |
識別番号:DOI | info:doi/10.1002/prp2.439 |
識別番号:DOI(リンク) | |
PubMed番号 | 30443347 |
抄録 | To evaluate the onset timing of musculoskeletal adverse events (MAEs) that develop during statin monotherapy and to determine whether concomitant drugs used concurrently with statin therapy shifts the onset timing of MAEs. Cases in which statins(atorvastatin, rosuvastatin, simvastatin, lovastatin, fluvastatin, pitavastatin, and pravastatin) were prescribed were extracted from the US Food and Drug Administration(FDA) Adverse Event Reporting System (FAERS) Data Files. The onset timing of MAEs during statin monotherapy was evaluated by determining the difference between statin start date and MAE onset date. The use of concomitant drugs with statin therapy was included in the analysis. Statins used in combination with concomitant drugs were compared with statin monotherapy to determine if the use of concomitant drugs shifted the onset timing of MAEs. The onset of MAEs was significantly faster with atorvastatin and rosuvastatin than with simvastatin. A difference in onset timing was not detected with other statins because the number of cases was too small for analysis. When evaluating concomitant drug use, the concomitant drugs that shifted the onset timing of MAEs could not be detected. Statins with strong low‐density lipoprotein cholesterol‐lowering effects (atorvastatin and rosuvastatin) contributed not only to a high risk of MAE onset, but also to a shorter timeto‐onset. No concomitant drug significantly shifted the onset timing of MAEs when used concurrently with statins. |
キーワード | |
注記 | 2018: e00439: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2018 The Authors. |
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このアイテムを表示する:URI | |