ID | JOS-md19120692 |
著者:名前 | |
著者:別形式 | Muramatsu, Hiroki / Akimoto, Naoe / Hashimoto, Michio / Sugibayashi, Kenji / Katakura, Masanori |
著者:カナ | |
著者:所属 | 城西大学薬学部薬科学科栄養生理学研究室 / 城西大学薬学部薬科学科栄養生理学研究室 / 島根大学医学部 / 城西大学薬学部薬科学科栄養生理学研究室 / 城西大学薬学部薬科学科栄養生理学研究室 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Nutritional Physiology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Nutritional Physiology / Shimane University, Faculty of Medicine / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Nutritional Physiology /Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Nutritional Physiology |
著者版フラグ | publisher |
出版者 | MDPI |
電子ISSN | 16603397 |
掲載誌名 | |
巻 | 19 |
号 | 12 |
刊行年月 | 2021-12 |
開始ページ | 1 |
終了ページ | 17 |
コンテンツ作成日 | 2021-11-16 |
コンテンツ修正日 | 2021-12-01 |
コンテンツ登録日 | 2022-02-14 |
識別番号:DOI | info:doi/10.3390/md19120692 |
識別番号:DOI(リンク) | |
抄録 | Arachidonic acid (ARA), an omega-6 (ω-6) polyunsaturated fatty acid (PUFA), is involved in the development and maintenance of renal functions, whereas docosahexaenoic acid (DHA) is an omega-3 (ω-3) PUFA that has anti-inflammatory effects and attenuates nephropathy. However, their effects on the progression of chronic kidney disease (CKD) remain unknown. The aim of this study was to assess the effects of feeding ARA, DHA, and ARA and DHA-containing diets on rats with 5/6 nephrectomized kidneys. Urine and feces were collected every 4 weeks, and the kidneys were collected at 16 weeks after surgery. Urinary albumin (U-ALB) excretion increased gradually with nephrectomy, but the U-ALB excretion was attenuated by feeding the rats with an ARA + DHA-containing diet. Reactive oxygen species (ROS) levels in the kidneys were lower in the ARA + DHA group than in the other groups. At 4 weeks after surgery, the lipid peroxide (LPO) levels in the plasma of the ARA + DHA groups decreased significantly after surgery compared to the control CKD group, but this did not happen at 16 weeks post-surgery. There was a significant negative correlation between LPO levels in the plasma at 4 weeks and creatinine clearance, and a positive correlation with urinary albumin levels. These results suggest that the combination of ARA and DHA inhibit the progress of early stage CKD. |
キーワード | |
注記 | Article No.692 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2021 by the authors.Licensee MDPI, Basel, Switzerland. |
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