ID | JOS-mmr.2020.11397 |
著者:名前 | |
著者:別形式 | Kikuchi, Hidetomo / Toyoda, Nana / Ezawa, Satoko / Yoshida, Shiori / Hibino, Yasuhide / Sunaga, Katsuyoshi |
著者:カナ | |
著者:所属 | 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 |
著者:所属(別形式) | Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | Athens |
出版者 | Spandidos Publications |
冊子ISSN | 17912997 |
電子ISSN | 17913004 |
掲載誌名 | |
巻 | 22 |
号 | 4 |
刊行年月 | 2020-07 |
開始ページ | 3525 |
終了ページ | 3532 |
コンテンツ作成日 | 2019-11-09 |
コンテンツ修正日 | 2020-06-04 |
コンテンツ登録日 | 2021-05-29 |
識別番号:DOI | info:doi/10.3892/mmr.2020.11397 |
識別番号:DOI(リンク) | |
PubMed番号 | 32945423 |
抄録 | α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the presence of the α‑glucosidase inhibitory activity in herbs, in which various functional effects have been known to occur, the present study investigated the effects of hot‑water extracts of 26 types of herbs on α‑glucosidase activity in an in vitro assay. The results indicated significant increases in the inhibition of α‑glucosidase activity in 1,000 µg/ml olive (P<0.01), white willow (P<0.01) and red rooibos hot‑water extracts. Furthermore, ≥50% inhibition of α‑glucosidase activity was determined to be significant in 1,000 µg/ml coltsfoot, green tea and bearberry hot‑water extracts. In addition, the effects of bearberry, green tea and coltsfoot hot‑water extracts on α‑glucosidase activity in vivo were evaluated according to the blood glucose levels (BGLs) in maltose and glucose load model rats. It was indicated that the administration of these three herb extracts significantly reduced the increasing BGLs after maltose loading until 0.5 h compared with the control group. However, only coltsfoot extract significantly reduced the increasing BGLs after glucose loading until 0.5 h compared with the control group. Thus, the present results may facilitate the understanding of a novel functionality in traditional herbs, which could be useful for the prevention of disease onset and progression, such as in hyperglycemia and type 2 diabetes. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © Spandidos Publications 2020 |
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