| ID | JOS-02507005-34-3543 |
| 著者：名前 | 島田, 智哉子/ 植沢, 芳広/ 石原, 真理子/ Kagaya, Hajime/ 金本, 大成/ 寺久保, 繁美/ 中島, 秀喜/ 高尾, 浩一/ Saito, Takayuki/ 杉田, 義昭/ 坂上, 宏 |
| 著者：別形式 | Shimada, Chiyako / Uesawa, Yoshihiro / Ishihara, Mariko / Kagaya, Hajime / Kanamoto, Taisei / Terakubo, shigemi / Nakashima, hideki / Takao, Koichi / Saito, Takayuki / Sugita, Yoshiaki / Sakagami, Hiroshi |
| 著者：カナ | シマダ, チヤコ/ ウエサワ, ヨシヒロ/ イシハラ, マリコ/ カガヤ, ハジメ/ カナモト, タイセイ/ テラクボ, シゲミ/ ナカシマ, ヒデキ/ タカオ, コウイチ/ サイトウ, タカユキ/ スギタ, ヨシアキ/ サカガミ, ヒロシ |
| 著者：所属 | 明海大学歯学部 / 明治薬科大学 / 明海大学歯学部 / 明治薬科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 明海大学歯学部 |
| 著者：所属(別形式） | Meikai University School of Dentistry, Department of Diagnostic and Therapeutic Sciences, Division of Pharmacology / Meiji Pharmaceutical University, Department of Clinical Pharmaceutics / Meikai University School of Dentistry, Department of Diagnostic and Therapeutic Sciences, Basic Chemistry / Meiji Pharmaceutical University, Department of Clinical Pharmaceutics / St. Marianna University School of Medicine / St. Marianna University School of Medicine / St. Marianna University School of Medicine / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Meikai University School of Dentistry, Department of Diagnostic and Therapeutic Sciences, Division of Pharmacology |
| 著者版フラグ | publisher |
| 出版地 | Athens |
| 出版者 | International Institute of Anticancer Research |
| NCID | AA12440673 |
| 冊子ISSN | 02507005 |
| 電子ISSN | 17917530 |
| 掲載誌名 | |
| 巻 | 34 |
| 号 | 7 |
| 刊行年月 | 2014-07 |
| 開始ページ | 3543 |
| 終了ページ | 3548 |
| コンテンツ作成日 | 2014-05-15 |
| コンテンツ登録日 | 2014-09-16 |
| 抄録 | Background: A total of 12 phenylpropanoid amides were subjected to quantitative structure?activity relationship (QSAR) analysis, based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to investigate on their biological activities. Materials and Methods: Cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines and three human oral normal cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Tumor selectivity was evaluated by the ratio of the mean CC50 (50% cytotoxic concentration) against normal oral cells to that against OSCC cell lines. Anti-HIV activity was evaluated by the ratio of CC50 to EC50 (50% cytoprotective concentration from HIV infection). Physicochemical, structural, and quantum-chemical parameters were calculated based on the conformations optimized by the LowModeMD method followed by density functional theory (DFT) method. Results: Twelve phenylpropanoid amides showed moderate cytotoxicity against both normal and OSCC cell lines. N-Caffeoyl derivatives coupled with vanillylamine and tyramine exhibited relatively higher tumor selectivity. Cytotoxicity against normal cells was correlated with descriptors related to electrostatic interaction such as polar surface area and chemical hardness, whereas cytotoxicity against tumor cells correlated with free energy, surface area and ellipticity. The tumor-selective cytotoxicity correlated with molecular size (surface area) and electrostatic interaction (the maximum electrostatic potential). Conclusion: The molecular size, shape and ability for electrostatic interaction are useful parameters for estimating the tumor selectivity of phenylpropanoid amides. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2014 International Institute of Anticancer Research |
| このアイテムを表示する：本文(pdf) |  ( 367.3KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
