| ID | JOS-02507005-34-5405 |
| 著者：名前 | 島田, 智哉子/ 植沢, 芳広/ Ishii-Nozawa, Reiko/ 石原, 真理子/ Kagaya, Hajime/ 金本, 大成/ 寺久保, 繁美/ 中島, 秀喜/ 高尾, 浩一/ 杉田, 義昭/ 坂上, 宏 |
| 著者：別形式 | Shimada, Chiyako / Uesawa, Yoshihiro / Ishii-Nozawa, Reiko / Ishihara, Mariko / Kagaya, Hajime / Kanamoto, Taisei / Terakubo, shigemi / Nakashima, hideki / Takao, Koichi / Sugita, Yoshiaki / Sakagami, Hiroshi |
| 著者：カナ | シマダ, チヤコ/ ウエサワ, ヨシヒロ/ イシイ-ノザワ, レイコ/ イシハラ, マリコ/ カガヤ, ハジメ/ カナモト, タイセイ/ テラクボ, シゲミ/ ナカシマ, ヒデキ/ タカオ, コウイチ/ スギタ, ヨシアキ/ サカガミ, ヒロシ |
| 著者：所属 | 明海大学歯学部 / 明治薬科大学 / 明治薬科大学 / 明海大学歯学部 / 明治薬科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 城西大学薬学部 / 城西大学薬学部 / 明海大学歯学部 |
| 著者：所属(別形式） | Meikai University School of Dentistry, Division of Pharmacology / Meiji Pharmaceutical University, Department of Clinical Pharmaceutics / Meiji Pharmaceutical University, Department of Clinical Pharmaceutics / Meikai University School of Dentistry, Basic Chemistry / Meiji Pharmaceutical University, Department of Clinical Pharmaceutics / St. Marianna University School of Medicine / St. Marianna University School of Medicine / St. Marianna University School of Medicine / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Meikai University School of Dentistry, Division of Pharmacology |
| 著者版フラグ | publisher |
| 出版地 | Athens |
| 出版者 | International Institute of Anticancer Research |
| NCID | AA12440673 |
| 冊子ISSN | 02507005 |
| 電子ISSN | 17917530 |
| 掲載誌名 | |
| 巻 | 34 |
| 号 | 10 |
| 刊行年月 | 2014-10 |
| 開始ページ | 5405 |
| 終了ページ | 5412 |
| コンテンツ作成日 | 2014-07-17 |
| コンテンツ登録日 | 2014-11-08 |
| 抄録 | Background: Fifteen 3-styrylchromones were subjected to quantitative structure?activity relationship (QSAR) analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to explore their biological activities. Materials and Methods: Cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines and three human oral normal cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Tumor-selectivity was evaluated by the ratio of the mean CC50 (50% cytotoxic concentration) against normal human oral cells to that against OSCC cell lines. Anti-HIV activity was evaluated by the ratio of CC50 to EC50 (50% cytoprotective concentration from HIV infection). Physicochemical, structural and quantum-chemical parameters were calculated based on the conformations optimized by the LowModeMD method followed by the density functional theory (DFT) method. Results: All 3-styrylchromone derivatives showed moderate-to-high tumor selectivity. Especially, compounds that have a methoxy group at 6-position of the chromone ring and hydroxyl group at 4’-position of phenyl group in styryl moiety [11] showed the highest tumor-selectivity. On the other hand, their cytotoxicity against normal cells showed good correlation to the descriptors that reflect hydrophobic interaction and molecular shapes. Conclusion: Multivariate statistics with chemical descriptors for the location of substituted group, molecular shape and electrostatic interaction may be useful for designing the most favorable compound with higher tumor selectivity. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2014 International Institute of Anticancer Research |
| このアイテムを表示する：本文(pdf) |  ( 242.0KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
