城西大学機関リポジトリJURACytotoxic activity of styrylchromones against human tumor cell lines

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Cytotoxic activity of styrylchromones against human tumor cell lines

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ID	JOS-0258851X-19-157
著者：名前	桃井, 香苗/杉田, 義昭/石原, 真理子/佐藤, 和恵/菊地, 寛高/橋本, 研/横江, 一朗/西川, 博文/藤沢, 盛一郎/坂上, 宏
著者：別形式	Momoi, Kanae / Sugita, Yoshiaki / Ishihara, Mariko / Satoh, Kazue / Kikuchi, Hirotaka / Hashimoto, Ken / Yokoe, Ichiro / Nishikawa, Hirofumi / Fijisawa, Seiichiro / Sakagami, Hiroshi
著者：カナ	モモイ, カナエ/スギタ, ヨシアキ/イシハラ, マリコ/サトウ, カズエ/キクチ, ヒロタカ/ハシモト, ケン/ヨコエ, イチロウ/ニシカワ, ヒロフミ/フジサワ, セイイチロウ/サカガミ, ヒロシ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 城西大学薬学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Josai University, Faculty of Pharmaceutical Sciences / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry
著者版フラグ	publisher
出版地	Athens
出版者	International Institute of Anticancer Research
NCID	AA10714348
冊子ISSN	0258851X
掲載誌名	In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research
巻	19
号	1
刊行年月	2005-01
開始ページ	157
終了ページ	164
コンテンツ作成日	2004-06-21
コンテンツ登録日	2013-01-29
抄録	A total of 6 newly-synthesized styrylchromones (SC-1~C-6) were compared for their cytotoxic activity against three normal oral human cells (gingival fibroblast HGF, pulp cell HPC, periodontal ligament fibroblast HPLF) and four human tumor cell lines (squamous cell carcinoma HSC-2, HSC-3, submandibular gland carcinoma HSG, promyelocytic leukemia HL-60). All compounds showed higher cytotoxic activity against tumor cell lines than against normal cells. Among the 6 compounds, SC-3, SC-4 and SC-5, which have one to three methoxy groups, showed higher tumor specificity and water solubility. The cytotoxic activity of SC-3 and SC-5 was slightly reduced by a lower concentration of NADH, a quinone reductase, but that of SC-3 was enhanced by higher concentrations of NADH, possibly due to demethylation of the methoxy groups. Agarose gel electrophoresis demonstrated that SC-3 and SC-5 induced internucleosomal DNA fragmentation in HL-60 cells and production of large DNA fragment in HSC-2 cells. Both SC-3 and SC-5 enhanced the enzymatic activity to cleave the substrates for caspases 3, 8 and 9, suggesting the activation of both extrinsic and intrinsic apoptosis pathways. ESR spectroscopy showed that these compounds produced no detectable amount of radical and did not scavenge superoxide anion generated by the hypoxanthine-xanthine oxidase reaction. The highly tumor-specific cytotoxic action and apoptosis-inducing capability of SC-3 and SC-5 suggest their applicability for cancer chemotherapy.
キーワード	Styrylchromones/cytotoxic activity/oral tumor cells/tumor specificity/DNA fragmentation/caspase
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
このアイテムを表示する：本文(pdf)	( 367.9KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-0258851X-19-157

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