ID JOS-0258851X-20-651
著者：名前 著者：別形式 Schelz, Zsuzsanna / Molnar, Joseph / Fogliano, Vincenzo / Ferracane, Rosalia / Pernice, Rita / Shirataki, Yoshiaki / Motohashi, Noboru
著者：カナ 著者：所属 University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology / University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology / University of Naples, Department of Food Sciences / University of Naples, Department of Food Sciences / University of Naples, Department of Food Sciences / 城西大学薬学部 / 明治薬科大学
著者：所属(別形式） University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology / University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology / University of Naples, Department of Food Sciences / University of Naples, Department of Food Sciences / University of Naples, Department of Food Sciences / Josai University, Faculty of Pharmaceutical Sciences / Meiji Pharmaceutical University
著者版フラグ publisher
出版地 Athens
出版者 International Institute of Anticancer Research
NCID AA10714348
冊子ISSN 0258851X
掲載誌名 巻 20
号 5
刊行年月 2006-09
開始ページ 651
終了ページ 656
コンテンツ作成日 2006-06-21
コンテンツ登録日 2011-07-31
NII論文ID 120005518453
識別番号：その他 1050282677773276160
抄録 In earlier experiments, the MDR (multidrug resistance)-reversal activities of Anastasia Black (Russian black sweet pepper) extracts had been analysed. Recently, the most effective MDR reversing extracts and fractions have been separated by HPLC (high-performance liquid chromatography, for carotenoids) and LC-MS-MS (HPLC combined with mass spectrometry, for phenolic compounds) methods. As a result of the analytical studies, the following flavonoids had been identified: feruloyl glucopyranoside, quercetin rhamnopyranoside glucopyranoside, luteolin glucopyranoside arabinopyranoside, apigenin glucopyranoside arabinopyranoside, quercetin rhamnopyranoside, luteolin arabinopyranoside diglucopy-ranoside, hesperidine and luteolin glucuronide. According to the literature, the aglycones of these phenolic compounds exhibit MDR-reversal activity in vitro, and the connection between the phenolic content of Anastasia Black and MDR-reversal action was therefore studied by different analytical methods. The results of this study revealed that the identified flavonoids of Anastasia Black may be only partially responsible for the modulation of the MDR of mouse lymphoma cells. Other lipophilic compounds, most probably carotenoids, present in Russian black sweet pepper may act as inhibitors of MDR reversal.
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言語 eng
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