| ID | JOS-08982100903062597 |
| 著者：名前 | 徳留, 嘉寛/ 内田, 礼奈/ 横手, 武司/ 藤堂, 浩明/ 羽田, 乃武子/ 金, 辰彦/ Yasuda, Junko/ 林, 秀徳/ 橋本, フミ惠/ 杉林, 堅次 |
| 著者：別形式 | Tokudome, Yoshihiro / Uchida, Raina / Yokote, Takeshi / Todo, Hiroaki / Hada, Nobuko / Kon, Tatsuhiko / Yasuda, Junko / Hayashi, Hidenori / Hashimoto, Fumie / Sugibayashi, Kenji |
| 著者：カナ | トクドメ, ヨシヒロ/ ウチダ, ライナ/ ヨコテ, タケシ/ トウドウ, ヒロアキ/ ハダ, ノブコ/ コン, タツヒコ/ ヤスダ, ジュンコ/ ハヤシ, ヒデノリ/ ハシモト, フミエ/ スギバヤシ, ケンジ |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / シャローム / 第一ファインケミカル株式会社 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Shalom, Co. Ltd / Daiichi Fine Chemical, Co. Ltd. / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical SciencesJosai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版者 | informa healthcare |
| NCID | AA10736806 |
| 冊子ISSN | 08982104 |
| 掲載誌名 | |
| 巻 | 20 |
| 号 | 1 |
| 刊行年月 | 2010-03 |
| 開始ページ | 49 |
| 終了ページ | 54 |
| コンテンツ作成日 | 2009-04-09 |
| コンテンツ登録日 | 2011-07-05 |
| 識別番号：DOI | info:doi/10.3109/08982100903062597 |
| 識別番号：DOI（リンク） | |
| 抄録 | Sphingomyelin-based liposomes were prepared and applied to the stratum corneum side or basal layer side of a three-dimensional cultured human skin model, and the increase in the type II ceramide (ceramide II) content of the cultured skin model was evaluated. The sphingomyelin-based liposomes were prepared by a high-pressure emulsification method, and the obtained liposomes were characterized; the particle diameter and zeta potential of the liposomes were 155.3 nm and -11.4 mV, respectively. Their spherical shape and lamella structure were observed by transmission electron microscopy. The sphingomyelin-based liposomes or saline were applied to the cultured skin model, and ceramide II was extracted from the skin model. The extracted ceramide II was separated by HPTLC and quantified by a densitometer. The amount of ceramide II in the cultured skin model was significantly increased by the application of the sphingomyelin-based liposomes compared with the non-application group. Thus, sphingomyelin-based liposomes are useful for enriching theceramide level in three dimensional cultured skin models. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 148.7KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
