ID JOS-09168451_72_3075
著者:名前 著者:別形式 Im, Ryang-Hyok / Mano, Hiroshi / Nakatani, Sachie / Shimizu, Jun / Wada, Masahiro
著者:カナ 著者:所属 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者:所属(別形式) Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ publisher
出版地 東京
出版者 日本農芸化学会
出版者:カナ ニホンノウゲイカガクカイ
出版者:別名 Japan Society for Bioscience, Biotechnology, and Agrochemistry
NCID AA10824164
冊子ISSN 09168451
電子ISSN 13476947
掲載誌名 巻 72
号 12
刊行年月 2008-12
開始ページ 3075
終了ページ 3083
コンテンツ作成日 2008-12-23
コンテンツ登録日 2012-07-28
識別番号:DOI info:doi/10.1271/bbb.70745
識別番号:DOI(リンク) 識別番号:その他 JOI:JST.JSTAGE/bbb/70745
抄録 Kothala himbutu is a traditional Ayurvedic medicinal plant used to treat diabetes. We aimed to evaluate the safety of an aqueous extract of Kothala himbutu stem (KTE) in normal mice. The mice were divided into two groups: one was administered KTE and the other distilled water for 3 weeks. During the test period, the groups showed no significant differences in body weight gain or plasma parameters, such as fasting blood glucose level, oral glucose tolerance test, or aspartate transaminase (AST) or alanine transaminase (ALT) activity. DNA microarray analysis revealed that expression of genes of known function, such as those for the stress response, ribosomal proteins, transcription, cell function, the inflammatory/immune response, and metabolism (xenobiotic, glutathione, etc.) remained largely unaffected by KTE. However some genes such as catechol-o-methyltransferase and succinyl-CoA synthetase were regulated by KTE, indicating that KTE is not toxic to normal mice and might be effective as a functional food.
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