城西大学機関リポジトリJURANovel experimental system as an alternative to animal experiments to study the skin permeation of drugs

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Novel experimental system as an alternative to animal experiments to study the skin permeation of drugs

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ID	JOS-13440411-14_2
著者：名前	関, 俊暢/指田, 達也/大島, 新司/江川, 祐哉/中川, 弘子/細谷, 治/從二, 和彦
著者：別形式	Seki, Toshinobu / Sashida, Tatsuya / Oshima, Shinji / Egawa, Yuya / Nakagawa, Hiroko / Hosoya, Osamu / Juni, Kazuhiko
著者：カナ	セキ, トシノブ/サシダ, タツヤ/オシマ, シンジ/エガワ, ユウヤ/ナカガワ, ヒロコ/ホソヤ, オサム/ジュウニ, カズヒコ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	author
出版地	東京
出版者	日本動物実験代替法学会
出版者：カナ	ニホンドウブツジッケンダイタイホウガッカイ
出版者：別名	Japanese Society for Alternative to Animal Experiments
NCID	AA11161787
冊子ISSN	13440411
掲載誌名	AATEX (Alternatives to Animal Testing and EXperimentation)
掲載誌名：翻訳	日本動物実験代替法学会機関誌
巻	14
号	2
刊行年月	2009-10
開始ページ	887
終了ページ	897
コンテンツ作成日	2009-10-31
コンテンツ登録日	2011-03-16
識別番号：DOI	info:doi/10.11232/aatex.14.887
識別番号：DOI（リンク）	https://doi.org/10.11232/aatex.14.887
抄録	A skin-mimicking artificial membrane consisting of a silicone membrane as a model stratum corneum and laminated dialysis membranes as a model of viable skin was prepared to imitate the layered structure of skin. The permeability of flurbiprofen (FP) through the laminated membranes agreed with that calculated, suggesting that the interfacial resistance between each membrane was negligible. When the FP concentration in the laminated membranes was determined by microdialysis, the observed concentration was similar to that calculated according to Fick’s law of diffusion. When bovine serum albumin (BSA) solution was placed between the dialysis membranes to mimic the protein leaching in skin, the FP permeation profiles through the membranes showed a long lag-time without dependence on the depth of the region of the inserted BSA from the surface. However, the FP concentration-time profiles in a region between the membranes showed dependence on the region of the inserted BSA. Since the FP concentration in the region and the permeation rates at steady-state were similar to those without BSA solution, BSA could act as a capacity factor to the delayed reaching to a steady-state. The skin mimicking laminated membranes will be useful to evaluate drug permeation quantitatively and to imitate some events which can happen in inflamed tissues in skin without requiring animals.
キーワード	skin absorption/microdialysis/artificial membrane/zero net flux/protein binding/経皮吸収/マイクロダイアリシス/人工膜/ゼロネットフラックス/タンパク結合
注記	Original Article
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
このアイテムを表示する：本文(pdf)	( 378.3KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-13440411-14_2

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