ID | JOS-13440411-15_2 |
著者:名前 | |
著者:別形式 | Kano, Satoshi / Todo, Hiroaki / Sugie, Kenichi / Fujimoto, Hidenori / Nakada, Keiichi / Tokudome, Yoshihiro / Hashimoto, Fumie / Sugibayashi, Kenji |
著者:カナ | |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
著者版フラグ | author |
出版地 | 東京 |
出版者 | 日本動物実験代替法学会 |
出版者:カナ | ニホン ドウブツ ジッケン ダイタイ ホウガッカイ |
出版者:別名 | Japanese Society for Alternative to Animal Experiments |
NCID | AA11161787 |
冊子ISSN | 13440411 |
掲載誌名 | |
掲載誌名:翻訳 | 日本動物実験代替法学会機関誌 |
巻 | 15 |
号 | 2 |
刊行年月 | 2010-10 |
開始ページ | 61 |
終了ページ | 70 |
コンテンツ作成日 | 2010-10-18 |
コンテンツ登録日 | 2011-02-01 |
識別番号:DOI | info:doi/10.11232/aatex.15.61 |
識別番号:DOI(リンク) | |
抄録 | Two reconstructed human skin models, EpiskinSM and EpiDermTM, have been approved as alternative membranes for skin corrosive/irritation experiments due to their close correlation with animal skin. Such reconstructed human skin models were evaluated as alternative membranes for skin permeation experiments. Seven drugs with different lipophilicities and almost the same molecular weight were used as test penetrants. Relationships were investigated between permeability coefficients (P values) of the seven drugs through six kinds of reconstructed cultured human skin models and human skin. A fairly good relationship in P values was observed between TESTSKINTM LSE-high (LSE-high) or EpiDermTM and human skin, suggesting that these reconstructed human skin models could be used as alternative membranes for skin permeation experiments. However, the partition parameter, KL, and diffusion parameter, DL-2 in these reconstructed human skin models were different to those of human skin. Especially, KL values in reconstructed human skin models were very different to those in human skin, even for LSE-high and EpiDermTM. Therefore, suitable reconstructed human skin models should be carefully selected on a case by case basis. |
キーワード | |
注記 | Original Article |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
このアイテムを表示する:本文(pdf) | ( 173.9KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |