城西大学機関リポジトリJURAThe inhibitory effect of kakkonto, Japanese traditional (Kampo) medicine, on brain penetration of oseltamivir carboxylate in mice with reduced blood-brain barrier function

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The inhibitory effect of kakkonto, Japanese traditional (Kampo) medicine, on brain penetration of oseltamivir carboxylate in mice with reduced blood-brain barrier function

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ID	JOS-1741427X_2015_917670
著者：名前	大原, 厚祐/大島, 新司/福田, 七実/落合, 佑未子/丸山, あゆみ/金室, 亜希/根岸, 彰生/本間, 精一/大嶋, 繁/秋元, 雅之/竹中, 伸五/小林, 大介
著者：別形式	Ohara, Kousuke / Oshima, Shinji / Fukuda, Nanami / Ochiai, Yumiko / Maruyama, Ayumi / Kanamuro, Aki / Negishi, Akio / Honma, Seiichi / Ohshima, Shigeru / Akimoto, Masayuki / Takenaka, Shingo / Kobayashi, Daisuke
著者：カナ	オオハラ, コウスケ/オオシマ, シンジ/フクダ, ナナミ/オチアイ, ユミコ/マルヤマ, アユミ/カナムロ, アキ/ネギシ, アキオ/ホンマ, セイイチ/オオシマ, シゲル/アキモト, マサユキ/タケナカ, シンゴ/コバヤシ, ダイスケ
著者：所属	城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 温故堂漢方あけぼの薬局 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Onko-Do Kampo Akebono Yakkyoku Co., Ltd. / Josai University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版者	Hindawi Publishing Corporation
NCID	AA11968793
冊子ISSN	1741427X
電子ISSN	17414288
掲載誌名	Evidence-Based Complementary and Alternative Medicine
巻	2015
号	917670
刊行年月	2015-01-31
開始ページ	1
終了ページ	11
コンテンツ作成日	2014-09-30
コンテンツ修正日	2015-01-31
コンテンツ登録日	2015-02-17
識別番号：DOI	info:doi/10.1155/2015/917670
識別番号：DOI（リンク）	http://dx.doi.org/10.1155/2015/917670
抄録	Oseltamivir phosphate (OP) is used to treat influenza virus infections. However, its use may result in central nervous system (CNS) adverse effects. In Japan, OP is used with Kampo formulations to improve clinical effectiveness. We evaluated the potential for using Kampo formulations to reduce CNS adverse effects by quantifying the CNS distribution of oseltamivir and its active metabolite oseltamivir carboxylate (OC) when administered with maoto and kakkonto. We administered lipopolysaccharide (LPS) by intraperitoneal injection to C57BL/6 mice to reduce blood-brain barrier function. Saline, maoto, and kakkonto were administered orally at the same time as LPS. OP was orally administered 4 hours after last LPS injection and the migration of oseltamivir and OC was examined. Additionally, we examined the brain distribution of OC following intravenous administration. Changes in OC concentrations in the brain suggest that in comparison to LPS-treated control mice, both Kampo formulations increased plasma levels of OC, thereby enhancing its therapeutic effect. Additionally, our findings suggest kakkonto may not only improve the therapeutic effect of oseltamivir but also reduce the risk of CNS-based adverse effects. In considering these findings, it should be noted that administration of kakkonto during periods of inflammation has led to increased OAT3 expression.
キーワード	blood-brain barrier/kakkonto/central nervous system-adverse effects/oseltamivir/maoto
注記	Article ID 917670 Open access journals
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	c2015 Kousuke Ohara et al. This is open access article distributed under teh Creative Commons Attribution License.
このアイテムを表示する：本文(pdf)	( 1.8MB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-1741427X_2015_917670

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