| ID | JOS-20902077_2016_8723139 |
| 著者：名前 | |
| 著者：別形式 | Ezawa, Toshinari / Inoue, Yutaka / Tunvichien, Sujimon / Suzuki, Rina / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / Thailand, Srinakharinwirot University / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Thailand, Srinakharinwirot University, Faculty of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版地 | New York |
| 出版者 | Hindawi Publishing Corporation |
| 冊子ISSN | 20902069 |
| 電子ISSN | 20902077 |
| 掲載誌名 | |
| 巻 | 2016 |
| 号 | Article ID 8723139 |
| 刊行年月 | 2016 |
| 開始ページ | 1 |
| 終了ページ | 9 |
| コンテンツ作成日 | 2015-12-01 |
| コンテンツ修正日 | 2016-01-20 |
| コンテンツ登録日 | 2016-02-24 |
| 識別番号：URI | |
| 識別番号：DOI | info:doi/10.1155/2016/8723139 |
| 識別番号：DOI（リンク） | |
| 抄録 | Piperine (PP) is a pungent component in black pepper that possesses useful biological activities, however it is practically insoluble in water. The aim of the current study was to prepare a co-ground mixture (GM) of PP and β-cyclodextrin (βCD) (molar ratio of PP/βCD=1/1) and subsequently evaluate the solubility of PP and physicochemical properties of the GM. DSC thermal behavior of the GM showed the absence of melting peak of piperine. PXRD profile of the GM exhibited halo pattern, no characteristic peaks due to PP and βCD was observed. Based on Job’s plot, the PP/βCD complex in solution had a stoichiometric ratio of 1/1. Raman spectrum of the GM revealed scattering peaks assigned for the benzene ring (C=C), the methylene groups (CH2) and ether groups (C-O-C) of PP that were broaden and shifted to lower frequencies. SEM micrographs showed that particles in the GM were agglomerated and had rough surface, unlike pure PP and pure βCD particles. At 15 min of dissolution testing, the amount dissolved of PP in the GM was dramatically increased (about 16 times) compared to that of pure PP. Moreover the interaction between PP and βCD cavity were detected by 1H-1H NMR nuclear Overhauser effect spectroscopy NMR spectroscopy. |
| キーワード | |
| 注記 | Open Access. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright ? 2016 Toshinari Ezawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| このアイテムを表示する：URI | |
