| ID | JOS-21566976_9_1517 |
| 著者：名前 | |
| 著者：別形式 | Kikuchi, Hidetomo / Yuan, Bo / Hu, Xiaomei / Okazaki, Mari |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医療栄養学科 / 城西大学薬学部薬学科 / China Academy of Chinese Medical Sciences, Xiyuan Hospital / 城西大学薬学部薬学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition, Laboratory of Pharmacotherapy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacology / China Academy of Chinese Medical Sciences, Xiyuan Hospital / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacology |
| 著者版フラグ | publisher |
| 出版地 | 埼玉県坂戸市 |
| 出版者 | e-Century Publishing Corporation |
| 電子ISSN | 21566976 |
| 掲載誌名 | |
| 巻 | 9 |
| 号 | 8 |
| 刊行年月 | 2019-08 |
| 開始ページ | 1517 |
| 終了ページ | 1535 |
| コンテンツ作成日 | 2019-06-04 |
| コンテンツ修正日 | 2019-06-11 |
| コンテンツ登録日 | 2019-10-31 |
| PubMed番号 | 31497340 |
| 抄録 | Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the potential to invade and spread to other parts of the body, and continues to be one of the leading causes of death worldwide. Conventional cancer treatment modalities include antitumor drugs, surgical resection, locally targeted therapies such as radiation therapy. Along with improved understanding of the molecular pathogenesis of various cancers, generation and the use of smart targeted anti-cancer drugs have been challenged. The need for novel therapeutic strategies remains paramount given the sustained development of drug resistance, tumor recurrence, and metastasis. Development of new strategies aimed at improving chemotherapy sensitivity and minimizing the adverse side effects is thus essential for obtaining satisfied therapeutic outcomes for patients and enhancing their quality of life. Emerging evidence has reported that many cancer patients use either herbs employed in complementary therapies or dietary agents that influence cellular signaling worldwide. Numerous components of edible plants, collectively termed phytochemicals that have beneficial effects for health, are being reported increasingly in the scientific literature. Of those, flavonoids have attracted much attention by virtue of its wide variety of biological functions including antioxidant, anti-inflammatory, and anticancer activity. In this review, we highlight the molecular mechanisms underlying its multiple pharmacological effects, especially focusing on cancer chemoprevention. We further discuss possible strategies to develop anticancer therapy by combining flavonoids nutraceuticals and conventional chemotherapeutic agents. We also highlight numerous pharmacokinetic challenges such as bioavailability, drug-drug interactions, which are still fundamental questions concerning its future clinical application. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © AJCR 2019 |
| このアイテムを表示する：本文(pdf) |  ( 578.4KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
