城西大学機関リポジトリJURAA survey of subcutaneous blood flow in patients with SMID and subcutaneous ceftazidime administration using mentholated warm compresses in healthy subjects

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A survey of subcutaneous blood flow in patients with SMID and subcutaneous ceftazidime administration using mentholated warm compresses in healthy subjects

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ID	JOS-JIMR-15-0416
著者：名前	海老原, 毅/大島, 新司/安田, 優子/沖田, 光良/大原, 厚祐/根岸, 彰生/大嶋, 繁/岩崎, 博之/米山, 明/北住, 映二/小林, 大介
著者：別形式	Ebihara, Tsuyoshi / Oshima, Shinji / Yasuda, Yuko / Okita, Mitsuyoshi / Ohara, Kousuke / Negishi, Akio / Ohshima, Shigeru / Iwasaki, Hiroyuki / Yoneyama, Akira / Kitazumi, Eiji / Kobayashi, Daisuke
著者：カナ	エビハラ, ツヨシ/オオシマ, シンジ/ヤスダ, ユウコ/オキタ, ミツヨシ/オオハラ, コウスケ/ネギシ, アキオ/オオシマ, シゲル/イワサキ, ヒロユキ/ヨネヤマ, アキラ/キタズミ, エイジ/コバヤシ, ダイスケ
著者：所属	心身障害児総合医療療育センター薬剤科 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学大学院薬学研究科 / 城西大学薬学部 / 城西大学薬学部 / 心身障害児総合医療療育センター小児科 / 心身障害児総合医療療育センター小児科 / 心身障害児総合医療療育センター小児科 / 城西大学薬学部
著者：所属(別形式）	National Rehabilitation Centre for Children with Disabilities, Department of Pharmacy Services / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai International University, Graduate School of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / National Rehabilitation Centre for Children with Disabilities, Department of Paediatrics / National Rehabilitation Centre for Children with Disabilities, Department of Paediatrics / National Rehabilitation Centre for Children with Disabilities, Department of Paediatrics / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版者	Sage
NCID	AA00700686
冊子ISSN	03000605
電子ISSN	14732300
掲載誌名	Journal of International Medical Research
巻	44
号	2
刊行年月	2016-02-17
コンテンツ作成日	2015-08-24
コンテンツ修正日	2017-01-25
コンテンツ登録日	2016-02-26
識別番号：DOI	info:doi/10.1177/0300060515625431
識別番号：DOI（リンク）	http://dx.doi.org/10.1177/0300060515625431
抄録	Objectives To investigate subcutaneous blood flow rate (SBFR) in healthy volunteers and patients with severe motor and intellectual disabilities (SMID), and evaluate the effect of mentholated warm compresses (MWCs) on SBFR and subcutaneous ceftazidime absorption in healthy volunteers. Methods SBFR at the forearm, chest and abdomen were evaluated in Japanese healthy volunteers and in adults with SMID. The effects of MWCs on blood flow rate and ceftazidime pharmacokinetics were evaluated in healthy volunteers. Results SBFR was significantly lower in the forearms of female patients with SMID (n?=?11) than in the forearms of healthy females (n?=?6); it was not significantly lower in the abdomen or chest. There were no significant differences between male patients (n?=?18) or controls (n?=?12) in SBFR at any site. MWC application increased SBFR 1.3- to 2.0-fold compared with baseline in healthy controls (n?=?6). MWC application increased ceftazidime maximum blood concentration, SBFR and time above mutant prevention concentration in a single healthy subject. Conclusions Abdominal SBFR in patients with SMID did not differ from that of healthy subjects. MWC application increases SBFR and subcutaneous drug absorption rate in healthy humans.
キーワード	Severe motor and intellectual disabilities/mentholated warm compress/subcutaneous administration/blood flow rate, mutant prevention concentration
注記	Open Access.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
権利	This is an Open Access article. Copyright © 2017 by SAGE Publications Ltd, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses.
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