城西大学機関リポジトリJURALow-Dose Sodium Nitrite Fluid Resuscitation Prevents Lethality From Crush Syndrome by Improving Nitric Oxide Consumption and Preventing Myoglobin Cytotoxicity in Kidney in A Rat Model

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Low-Dose Sodium Nitrite Fluid Resuscitation Prevents Lethality From Crush Syndrome by Improving Nitric Oxide Consumption and Preventing Myoglobin Cytotoxicity in Kidney in A Rat Model

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ID	JOS-SHK.0000000000000817
著者：名前	村田, 勇/三宅, 祐美/高橋, 直美/鈴木, 隆太/藤原, 貴之/佐藤, 裕志/井上, 裕/小林, 順/金本, 郁男
著者：別形式	Murata, Isamu / Miyake, Yumi / Takahashi, Naomi / Suzuki, Ryuta / Fujiwara, Takayuki / Sato, Yuji / Inoue, Yutaka / Kobayashi, Jun / Kanamoto, Ikuo
著者：カナ	ムラタ, イサム/ミヤケ, ユミ/タカハシ, ナオミ/スズキ, リュウタ/フジワラ, タカユキ/サトウ, ユウジ/イノウエ, ユタカ/コバヤシ, ジュン/カナモト, イクオ
著者：所属	城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医薬品安全性学研究室 / 城西大学薬学部医療栄養学科病態解析学 / 城西大学薬学部医薬品安全性学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology
著者版フラグ	author
出版者	Lippincott Williams & Wilkins
冊子ISSN	10732322
電子ISSN	15400514
掲載誌名	SHOCK
巻	48
号	1
刊行年月	2017-07
開始ページ	112
終了ページ	118
コンテンツ作成日	2016-09-28
コンテンツ修正日	2016-11-30
コンテンツ登録日	2018-07-26
識別番号：DOI	info:doi/10.1097/SHK.0000000000000817
識別番号：DOI（リンク）	https://doi.org/10.1097/SHK.0000000000000817
PubMed番号	27941593
抄録	Objective: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from pressure. CS has a high mortality, even when patients receive fluid therapy. We examined whether administration of NaNO2-containing fluid can improve survival in a rat model of CS.Design: The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into six groups: sham; CS with no treatment; CS with normal saline treatment; CS with normal saline + 25 mEq/L bicarbonate treatment; and CS with normal saline + 200 or 500 μmol/kg NaNO2.Measurements and Main Results: Blood and tissue samples were collected for histological and biochemical analyses at predetermined time points before and after reperfusion. Ischemic compression of rat hind limbs reduced nitrite content in the crushed muscle, and subsequent reperfusion resulted in reactive oxygen species-induced circulatory dysfunction and systemic inflammation. Rats treated with 200 μmol/kg NaNO2 showed increased nitric oxide (NO) levels, blood circulation, and neoangiogenesis, decreased generation of reactive oxygen species, and suppression of the inflammatory response, leading to complete recovery.Conclusions: Treatment with 200 μmol/kg NaNO2 prevents muscle damage induced by ischemia reperfusion via the protective effects of NO and suppression of systemic inflammation, thereby increasing survival rates in CS.
キーワード	Anti-inflammatory/crush syndrome/fluid resuscitation/nitric oxide/sodium nitrite
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2016 by the Shock Society
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-SHK.0000000000000817

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