城西大学機関リポジトリJURATRPV1 Agonist Monoacylglycerol Increases UCP1 Content in Brown Adipose Tissue and Suppresses Accumulation of Visceral Fat in Mice Fed a High-Fat and High-Sucrose Diet

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TRPV1 Agonist Monoacylglycerol Increases UCP1 Content in Brown Adipose Tissue and Suppresses Accumulation of Visceral Fat in Mice Fed a High-Fat and High-Sucrose Diet

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ID	JOS-bbb.100850
著者：名前	Iwasaki, Yusaku/Tamura, Yasuko/Inayoshi, Kimiko/Narukawa, Masataka/古旗, 賢二/千葉, 大成/村木, 悦子/角田, 伸代/渡辺, 達夫
著者：別形式	Iwasaki, Yusaku / Tamura, Yasuko / Inayoshi, Kimiko / Narukawa, Masataka / Kobata, Kenji / Chiba, Hiroshige / Muraki, Etsuko / Tsunoda, Nobuyo / Watanabe, Tatsuo
著者：カナ	イワサキ, ユウサク/タムラ, ヤスコ/イナヨシ, キミコ/ナルカワ, マサタカ/コバタ, ケンジ/チバ, ヒロシゲ/ムラキ, エツコ/ツノダ, ノブヨ/ワタナベ, タツオ
著者：所属	静岡県立大学 / 静岡県立大学 / 静岡県立大学 / 静岡県立大学 / 城西大学 / 城西大学 / 城西大学 / 城西大学 / 静岡県立大学
著者：所属(別形式）	University of Shizuoka，Graduate School of Nutritional and Environmental Sciences / University of Shizuoka，Graduate School of Nutritional and Environmental Sciences / University of Shizuoka，School of Food and Nutritional Sciences / University of Shizuoka，Graduate School of Nutritional and Environmental Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / University of Shizuoka，Graduate School of Nutritional and Environmental Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本農芸化学会
出版者：カナ	ニホンノウゲイカガクカイ
出版者：別名	Japan Society for Bioscience, Biotechnology, and Agrochemistry
NCID	AA10824164
冊子ISSN	09168451
電子ISSN	13476947
掲載誌名	Bioscience, Biotechnology, and Biochemistry
巻	75
号	5
刊行年月	2011-05
開始ページ	904
終了ページ	909
コンテンツ作成日	2010-11-30
コンテンツ登録日	2011-10-25
識別番号：URI	http://www.jstage.jst.go.jp/article/bbb/75/5/904/_pdf/-char/ja/
識別番号：DOI	info:doi/10.1271/bbb.100850
識別番号：DOI（リンク）	http://dx.doi.org/10.1271/bbb.100850
識別番号：その他	JOI:JST.JSTAGE/bbb/100850
抄録	The administration of such a transient receptor potential vanilloid 1 (TRPV1) agonist as capsaicin, which is a pungent ingredient of red pepper, promotes energy metabolism and suppresses visceral fat accumulation. We have recently identified monoacylglycerols (MGs) having an unsaturated long-chain fatty acid as the novel TRPV1 agonist in foods. We investigated in this present study the effects of dietary MGs on uncoupling protein 1 (UCP1) expression in interscapular brown adipose tissue (IBAT) and on fat accumulation in mice fed with a high-fat, high-sucrose diet. The MG30 diet that substituted 30% of all lipids for MGs (a mixture of 1-oleoylglycerol, 1-linoleoylglycerol and 1-linolenoylglycerol) significantly increased the UCP1 content of IBAT and decreased the weight of epididymal white adipose tissue, and the serum glucose, total cholesterol and free fatty acid levels. The diet containing only 1-oleoylglycerol as MG also increased UCP1 expression in IBAT. MGs that activated TRPV1 also therefore induced the expression of UCP 1 and prevented visceral fat accumulation as well as capsaicin.
キーワード	monoacylglycerol/transient receptor potential vaniloid 1 (TRPV1)/uncoupling protein 1/obesity/capsaicin
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
このアイテムを表示する：本文(pdf)	( 141.8KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bbb.100850

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