| ID | JOS-bpb.16.254 |
| 著者：名前 | |
| 著者：別形式 | Kobayashi, Daisuke / Matsuzawa, Takayasu / Sugibayashi, Kenji / Morimoto, Yasunori / Kobayashi, Masayuki / Kimura, Masayuki |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 株式会社TTS技術研究所 / 城西大学薬学部 / 城西大学薬学部 / 埼玉医科大学総合医療センター外科 / 埼玉医科大学総合医療センター薬剤部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Research Institute of TTS Technology / Josai University, Faculty of Pharmaceutical Sciences /Josai University, Faculty of Pharmaceutical Sciences / Saitama Medical School, Saitama Medical Center, Department of Surgery / Saitama Medical School, Saitama Medical Center, Department of Pharmacy Services |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA10885497 |
| 冊子ISSN | 0031-6903 |
| 電子ISSN | 1347-5231 |
| 掲載誌名 | |
| 巻 | 16 |
| 号 | 3 |
| 刊行年月 | 1993-03 |
| 開始ページ | 254 |
| 終了ページ | 258 |
| コンテンツ作成日 | 1992-06-22 |
| コンテンツ登録日 | 2018-09-27 |
| 識別番号：DOI | info:doi/10.1248/bpb.16.254 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 8364469 |
| NII論文ID | 110003640226 |
| 抄録 | Effect of the simultaneous use of l-menthol and ethanol on the skin permeation of six potent cardiovascular agents : nicardipine hydrochloride, atenolol, captopril, nifedipine, vinpocetine and nilvadipine (in hydrophilic order) was investigated to evaluate the feasibility of their use in a transdermal therapeutic system (TTS). In vitro diffusion experiments were carried out using excised hairless rat and human skin, and the application area of TTS required for the minimum therapeutic effect was estimated by a simple pharmacokinetic calculation. Marked enhancing effect by the l-menthol-ethanol system was found independent of drug lipophilicity, but the mode action was dependent on the lipophilicity of the drug. The action of the system on lipophilic drugs (nifedipine, vinpocetine and nilvadipine) was mainly due to their increase in solubility in the system, while that on hydrophilic (or water soluble) drugs (nicardipine hydrochloride, atenolol and captopril) was the result of increase in their skin permeability coefficient. This enhancing effect was adequate to assure their minimum effective concentration (MEC) in human. The area of application of a drug to maintain the MEC was calculated to be 0.15 cm2 for hydrophilic or water soluble drugs and 3.7-13 cm2 for lipophilic drugs. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 1993 Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 764.4KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
