城西大学機関リポジトリJURAInfluence of Composition of l-Menthol-Ethanol-Water Ternary Solvent System on the Transdermal Delivery of Morphine Hydrochloride

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Influence of Composition of l-Menthol-Ethanol-Water Ternary Solvent System on the Transdermal Delivery of Morphine Hydrochloride

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ID	JOS-bpb.16.600
著者：名前	和田, 好夫/中島, 加恵/山崎, 純一/関, 俊暢/杉林, 賢次/森本, 雍憲
著者：別形式	Wada, Yoshio / Nakajima, Kae / Yamazaki, Junichi / Seki, Toshinobu / Sugibayashi, Kenji / Morimoto, Yasunori
著者：カナ	ワダ, ヨシオ/ナカジマ, カエ/ヤマザキ, ジュンイチ/セキ, トシノブ/スギバヤシ, ケンジ/モリモト, ヤスノリ
著者：所属	株式会社TTS技術研究所 / 株式会社TTS技術研究所 / 株式会社TTS技術研究所 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Research Institute of TTS Technology Co., Ltd., / Research Institute of TTS Technology Co., Ltd., / Research Institute of TTS Technology Co., Ltd., / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	0031-6903
電子ISSN	1347-5231
掲載誌名	Biological and Pharmaceutical Bulletin
巻	16
号	6
刊行年月	1993-06
開始ページ	600
終了ページ	603
コンテンツ作成日	1992-12-07
コンテンツ登録日	2018-09-27
識別番号：DOI	info:doi/10.1248/bpb.16.600
識別番号：DOI（リンク）	http://doi.org/10.1248/bpb.16.600
PubMed番号	8364514
NII論文ID	110003640305
抄録	The influence of concentration of each component in l-menthol-ethanol-water ternary solvent system (MEW system) on the skin permeation of morphine hydrochloride (MPH) was investigated in hairless rats. The cumulative amount of MPH permeated through the excised abdominal skin over 8 h (Q-8) was selected as an index of skin permeability. With changing MPH concentration over a wide range from 0.01 to 10% in a MEW system (5% l-menthol and 40% ethanol), the values of Q-8 were proportional to MPH concentration. The concentration was fixed at 1% for the following experiments. For the effect of the concentration of l-menthol at 40% ethanol, the maximum Q-8 was observed at 5% l-menthol, and no greater enhancement of Q-8 was obtained by increasing l-menthol concentration above that. In the ethanol effect at 5% l-menthol, the maximum Q-8 was observed at 45% ethanol. When 2-propanol and methanol, which are more lipophilic and hydrophilic than ethanol, respectively, were used instead of ethanol, the maximum values of Q-8 were observed at 40 and 55%. The maximum values for Q-8 were obtained in the vicinity of the solubility of l-menthol in the MEW system in all cases, suggesting that the skin permeation enhancing effect of the system is dependent on the thermodynamic activity of l-menthol.
キーワード	morphine hydrochloride/skin permeation/penetration enhancer/l-menthol-ethanol-water ternary solvent system
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 1993 Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.16.600

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