城西大学機関リポジトリJURAEvaluation of Enhancers to Increase Nasal Absorption Using Ussing Chamber Technique

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Evaluation of Enhancers to Increase Nasal Absorption Using Ussing Chamber Technique

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ID	JOS-bpb.17.316
著者：名前	細谷, 健一/久保, 浩之/夏目, 秀視/杉林, 賢次/森本, 雍憲
著者：別形式	Hosoya, Kenichi / Kubo, Hiroyuki / Natsume, Hideshi / Sugibayashi, Kenji / Morimoto, Yasunori
著者：カナ	ホソヤ, ケンイチ/クボ, ヒロユキ/ナツメ, ヒデシ/スギバヤシ, ケンジ/モリモト, ヤスノリ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	0031-6903
電子ISSN	1347-5231
掲載誌名	Biological and Pharmaceutical Bulletin
巻	17
号	2
刊行年月	1994-02
開始ページ	316
終了ページ	322
コンテンツ作成日	1993-07-19
コンテンツ修正日	1993-09-24
コンテンツ登録日	2018-09-27
識別番号：DOI	info:doi/10.1248/bpb.17.316
識別番号：DOI（リンク）	http://doi.org/10.1248/bpb.17.316
PubMed番号	7515747
NII論文ID	110003640531
抄録	The effects of eight prospective absorption enhancers on the nasal mucosa in rabbit have been assessed using an in vitro Ussing chamber technique. Sodium taurodihydrofusidate (STDHF), sodium deoxycholate (DC), polyoxyethylene-9-lauryl ether (BL-9), lysophosphatidylcholine (LPC) and sodium dodecyl sulfate (SDS) were found to possess relatively high protein leaching activity, while sodium glycocholate (GC), sodium taurocholate (TC) and EDTA had relatively low activity. The permeation of fluorescein isothiocyanate-labeled dextran (FD, M.W. 9400) as a model drug across the nasal mucosa was found to be greater in the presence of these enhancers. Their enhancement ratio was found to be in the order of BL-9>STDHF>SDS>LPC>DC>EDTA>GC>TC, which correlated with the protein leaching activity. The differences in protein leaching and enhancement ratio dependent on the magnitude of change of membrane resistance (△Rm), indicating that these enhancers damaged the membrane and increased FD permeation. △Rm thus appears to be a useful indicator by which one can estimate nasal mucosa damage by the enhancers.
キーワード	absorption enhancer/Ussing chamber/nasal mucosa/membrane resistance/toxicity/nasal delivery
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 1994 Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.17.316

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