ID | JOS-bpb.31.340 |
著者:名前 | 塩田, 泰生/ 清田, 憲吾/ Kobayashi, Teruaki/ Kano, Shojiro/ Kawamura, Mitsunobu/ Matsushima, Teruhiko/ Miyazaki, Shigeru/ Uchino, Katsuyoshi/ 橋本, フミ惠/ 林, 秀徳 |
著者:別形式 | Shiota, Yasuo / Kiyota, Kengo / Kobayashi, Teruaki / Kano, Shojiro / Kawamura, Mitsunobu / Matsushima, Teruhiko / Miyazaki, Shigeru / Uchino, Katsuyoshi / Hashimoto, Fumie / Hayashi, Hidenori |
著者:カナ | シオタ, ヤスオ/ キヨタ, ケンゴ/ コバヤシ, テルアキ/ カノウ, ショウジロウ/ カワムラ, ミツノブ/ マツシマ, テルヒコ/ ミヤザキ, シゲル/ ウチノ, カツヨシ/ ハシモト, フミエ/ ハヤシ, ヒデノリ |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 東京逓信病院臨床検査科 / 東京逓信病院臨床検査科 / 東京逓信病院内科 / 筑波記念病院内科 / 東京逓信病院薬局 / 城西大学薬学部 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Tokyo Teishin Hospital, Department of Clinical Laboratory / Tokyo Teishin Hospital, Department of Clinical Laboratory / Tokyo Teishin Hospital, Department of Internal Medicine / Tsukuba Memorial Hospital, Department of Internal Medicine / Tokyo Teishin Hospital, Department of Internal Medicine / Tokyo Teishin Hospital, Department of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬学会 |
出版者:カナ | ニホンヤクガクカイ |
出版者:別名 | The Pharmaceutical Society of Japan |
NCID | AA10885497 |
冊子ISSN | 09186158 |
電子ISSN | 13475215 |
掲載誌名 | |
巻 | 31 |
号 | 3 |
刊行年月 | 2008-03 |
開始ページ | 340 |
終了ページ | 347 |
コンテンツ作成日 | 2007-09-14 |
コンテンツ修正日 | 2007-12-04 |
コンテンツ登録日 | 2015-03-09 |
識別番号:DOI | info:doi/10.1248/bpb.31.340 |
識別番号:DOI(リンク) | |
抄録 | We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Serum dolichol was evaluated by a reverse-phase HPLC method. After centrifugation, the serum dolichol found in healthy controls was mainly associated with medium-sized particles of the high-density lipoprotein (HDL) fraction. For patients with hyperbetalipoproteinemia, serum dolichol was also associated with the medium HDL fractions. However, for hyperalphalipoproteinemia patients the levels of large HDL and serum dolichol were increased, and serum dolichol was mainly associated with the large HDL fraction. On laboratory tests of components, the dolichol level was not correlated with the values for markers of the liver and biliary system, with the values of renal function markers, with creatine kinase activity, amylase activity or uric acid concentration, but was correlated with total cholesterol, HDL-cholesterol and apoA-I concentrations, and with lactate dehydrogenase (LDH) activity. These results suggest that serum dolichol exclusively localized in HDL, and in subpopulation, that in normocholesterolemia or hyperbeta-cholesterolemia is associated with HDL3, which is small sized and high density HDL, however, that in hyperalphacholesterolemia is associated with HDL2, which is large sized and lower density HDL. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright c2008 The Pharmaceutical Society of Japan |
このアイテムを表示する:本文(pdf) | ( 390.1KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |