城西大学機関リポジトリJURAExamination of the Expression of Cyclooxygenase-2 in Placenta Villi from Sufferers of Pregnancy Induced Hypertension

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Examination of the Expression of Cyclooxygenase-2 in Placenta Villi from Sufferers of Pregnancy Induced Hypertension

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ID	JOS-bpb.32.2053
著者：名前	大川原, 正喜/関, 博之/松岡, 菊美/橋本, フミ惠/林, 秀徳/武田, 省
著者：別形式	Okawara, Masaki / Seki, Hiroyuki / Matsuoka, Kikumi / Hashimoto, Fumie / Hayashi, Hidenori / Takeda, Satoru
著者：カナ	オオカワラ, マサキ/セキ, ヒロユキ/マツオカ, キクミ/ハシモト, フミエ/ハヤシ, ヒデノリ/タケダ, サトル
著者：所属	城西大学薬学部 / 埼玉医科大学総合医療センター産婦人科 / 埼玉医科大学総合医療センター産婦人科 / 城西大学薬学部 / 城西大学薬学部 / 埼玉医科大学総合医療センター産婦人科
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Saitama Medical University, Saitama Medical Center, Department of Obstetrics and Gynecology / Saitama Medical University, Saitama Medical Center, Department of Obstetrics and Gynecology / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Saitama Medical University, Saitama Medical Center, Department of Obstetrics and Gynecology
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	32
号	12
刊行年月	2009-12
開始ページ	2053
終了ページ	2056
コンテンツ作成日	2009-06-24
コンテンツ修正日	2009-09-24
コンテンツ登録日	2015-03-09
識別番号：DOI	info:doi/10.1248/bpb.32.2053
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.32.2053
抄録	Objectives: The purpose of this paper is to elucidate the roles of phospholipase A2 (PLA2), cyclooxygenase-2 (COX-2), and prostaglandin I2 (PGI2) synthase in pregnancy induced hypertension (PIH). Methods: In placentas from normal pregnant women and pregnant women with severe PIH, the enzyme expression of PLA2, COX-2, and PGI2 synthase was measured using real time reverse transcription-polymerase chain reaction (RT-PCR). Results: The expression of each enzyme was compared between normal (n=12) and PIH (n=12) groups. The expression levels of COX-2 and PGI2 synthase during PIH pregnancy were significantly decreased to about 51% and 68%, respectively, of their values in normal pregnancy. However, the expression of PLA2 was hardly changed by PIH. Conclusions: The decreases in COX-2 and PGI2 synthase expression in severe PIH placentas may be causal factors in the disruption of the PGI2?thromboxane A2 (TXA2) balance in favor of TXA2. The decrease in COX-2 was more marked than that of PGI2 synthase.
キーワード	pregnancy induced hypertension/cyclooxygenase/placenta/prostaglandin I2/phospholipase A2
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c2009 The Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 2.6MB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.32.2053

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