| ID | JOS-bpb.33.1915 |
| 著者：名前 | |
| 著者：別形式 | Seki, Toshinobu / Kiuchi, Takaaki / Seto, Hiroki / Kimura, Soichiro / Egawa, Yuya / Ueda, Hideo / Morimoto, Yasunori |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA10885497 |
| 冊子ISSN | 09186158 |
| 電子ISSN | 13475215 |
| 掲載誌名 | |
| 巻 | 33 |
| 号 | 11 |
| 刊行年月 | 2010-11 |
| 開始ページ | 1915 |
| 終了ページ | 1918 |
| コンテンツ作成日 | 2010-09-02 |
| コンテンツ登録日 | 2013-07-03 |
| 識別番号：DOI | info:doi/10.1248/bpb.33.1915 |
| 識別番号：DOI（リンク） | |
| 識別番号：その他 | JOI:JST.JSTAGE/bpb/33.1915 |
| 抄録 | The Renkin function was applied to characterize the penetration pathways through rat skin following different pretreatments. Nonmetabolic oligosaccharides and sugar alcohols, as model hydrophilic compounds, were applied simultaneously to the excised skin to obtain the equivalent cylindrical pore radius (R) and pore occupancy/length ratio (ε/L) for each skin piece. The R and ε/L values obtained were used to construct the simulation curves of the permeability coefficient (Pa)?molecular weight (MW). In the case of full-stripped skin, the Pa of the model compounds and separately obtained Pa of 5(6)-carboxyfluorescein (CF) showed good agreement with the simulation curve based on the Renkin function, suggesting that the viable epidermis and dermis in the full-stripped skin contained permeation pathways for hydrophilic compounds like aqueous channels. On the other hand, there was poor agreement of Pa with the simulation curve for skin pretreated with an ethanol-menthol mixed enhancer system and the observed Pa of CF in the pretreated skin was twice that calculated. The enhancer system might not be able to create aqueous channels in the lipid layer of the stratum corneum and could increase the permeation of CF in the layer in a different way. The analysis presented here will be useful not only for quantitative evaluation of drug permeation through aqueous channels in treated skins but also for investigation of the mechanism of skin-permeation enhancing techniques. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 111.4KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
