ID JOS-bpb.34.740
著者:名前 著者:別形式 Uchida, Masaki / Katoh, Takuya / Mori, Mutsuhiro / Maeno, Takuya / Ohtake, Kazuo / Kobayashi, Jun / Morimoto, Yasunori / Natsume, Hideshi
著者:カナ 著者:所属 城西大学薬学部 / 城西大学薬学部 / 旭化成ファーマ株式会社 / Kosei Chuo General Hospital, Department of Pharmacy / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者:所属(別形式) Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Asahi Kasei Pharma Corporation / Kosei Chuo General Hospital, Department of Pharmacy / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science /
著者版フラグ publisher
出版地 東京
出版者 日本薬学会
出版者:カナ ニホンヤクガクカイ
出版者:別名 The Pharmaceutical Society of Japan
NCID AA10885497
冊子ISSN 09186158
電子ISSN 13475215
掲載誌名 巻 34
号 5
刊行年月 2011-05
開始ページ 740
終了ページ 747
コンテンツ作成日 2011-02-28
コンテンツ登録日 2013-07-16
識別番号:DOI info:doi/10.1248/bpb.34.740
識別番号:DOI(リンク) 識別番号:その他 JOI:JST.JSTAGE/bpb/34.740
抄録 Recently, transnasal drug delivery has attracted a great deal of attention as an administration route to deliver drugs directly to the central nervous systems (CNS) and drug targeting of the CNS is expected to increase. In the present study, we investigated the possibility of using a transnasal delivery system for milnacipran, a serotonin?noradrenaline reuptake inhibitor (SNRI), by evaluating the transport to the systemic circulation and cerebrospinal fluid (CSF) and the pharmacological effect after intranasal (i.n.) administration. Moreover, the effect of chitosan as a bioadhesive material on the transport to the systemic circulation and CSF and the pharmacological effect after i.n. administration were evaluated. As a result, i.n. administration of milnacipran was found to produce a higher direct delivery to the CNS as well as to the systemic circulation, suggesting that this is a promising route of administration and an alternative to peroral (p.o.) administration. Furthermore, the i.n. co-administration with chitosan led to increased plasma and CSF concentrations and an enhanced pharmacological effect, evaluated by means of the forced swimming test. The results suggested that chitosan produced a long residence time of milnacipran in the nasal cavity due to its bioadhesive effect, leading to the enhanced transport of milnacipran from the systemic circulation to the CNS via the blood?brain barrier by an increase in systemic absorption as well as direct transport to the CNS, resulting in a higher antidepressant effect compared to that with p.o. administration.
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