城西大学機関リポジトリJURACharacterization of Fatty Acid Profile in the Liver of SHR/NDmcr-cp (cp/cp) Rats, a Model of the Metabolic Syndrome

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Characterization of Fatty Acid Profile in the Liver of SHR/NDmcr-cp (cp/cp) Rats, a Model of the Metabolic Syndrome

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ID	JOS-bpb.35.184
著者：名前	田中, 静代/八木, 裕理詠/山崎, 研/光本, 篤史/小林, 大介/工藤, なをみ/川嶋, 洋一
著者：別形式	Tanaka, Shizuyo / Yagi, Yurie / Yamazaki, Tohru / Mitsumoto, Atsushi / Kobayashi, Daisuke / Kudo, Naomi / Kawashima, Yoichi
著者：カナ	タナカ, シズヨ/ヤギ, ユリエ/ヤマザキ, トオル/ミツモト, アツシ/コバヤシ, ダイスケ/クドウ, ナオミ/カワシマ, ヨウイチ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 /
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai International University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science /
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	35
号	2
刊行年月	2012-02
開始ページ	184
終了ページ	191
コンテンツ作成日	2011-11-16
コンテンツ登録日	2013-07-16
識別番号：DOI	info:doi/10.1248/bpb.35.184
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.35.184
識別番号：その他	JOI:JST.JSTAGE/bpb/35.184
抄録	The fatty acid profile of hepatic lipid in spontaneously hypertensive rats (SHR)/NDmcr-cp (cp/cp) rats (SHR/NDcp), which offer an animal model of the metabolic syndrome, was characterized by comparing those in Wistar Kyoto rats (WKY), SHR, stroke-prone spontaneously hypertensive rats (SHRSP) and SHR/NDmcr-cp (+/+) rats (SHR/ND+) . Hierarchical clustering analysis revealed that SHR/NDcp and the other four strains and/or substrains of rats were clearly disparate in fatty acid profile of hepatic lipid and that the disparity observed was due to the drastic increases in the mass of monounsaturated fatty acids, especially palmitoleic acid and oleic acid, in the liver of SHR/NDcp. Activities of stearoyl-CoA desaturase (SCD) and palmitoyl-CoA chain elongase in hepatic microsomes of SHR/NDcp were markedly higher than those of WKY, SHR, SHRSP and SHR/ND+. Activities of palmitoleoyl-CoA chain elongase in the liver of SHR/NDcp were also higher, but to a lesser extent. mRNA levels of SCD1 and elongation of very long-chain fatty acids (Elovl6), but not Elovl5, in the liver of SHR/NDcp were remarkably higher than those of the other four groups of rats. These results suggest that the enhanced expressions of SCD1 and Elovl6 induced abnormalities in fatty acid profile in the liver of SHR/NDcp.
キーワード	fatty acid profile/palmitoleic acid/oleic acid/liver/SHR/NDmcr-cp (cp/cp) rat
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.35.184

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