城西大学機関リポジトリJURAThe Use of an Artificial Skin Model to Study Transdermal Absorption of Drugs in Inflamed Skin

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The Use of an Artificial Skin Model to Study Transdermal Absorption of Drugs in Inflamed Skin

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ID	JOS-bpb.35.203
著者：名前	大島, 新司/鈴木, 千尋/矢島, 里菜/江川, 祐哉/細谷, 治/從二, 和彦/関, 俊暢
著者：別形式	Oshima, Shinji / Suzuki, Chihiro / Yajima, Rina / Egawa, Yuya / Hosoya, Osamu / Juni, Kazuhiko / Seki, Toshinobu
著者：カナ	オオシマ, シンジ/スズキ, チヒロ/ヤジマ, リナ/エガワ, ユウヤ/ホソヤ, オサム/ジュウニ, カズヒコ/セキ, トシノブ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 /
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science /
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	35
号	2
刊行年月	2012-02
開始ページ	203
終了ページ	209
コンテンツ作成日	2011-11-25
コンテンツ登録日	2013-07-16
識別番号：DOI	info:doi/10.1248/bpb.35.203
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.35.203
識別番号：その他	JOI:JST.JSTAGE/bpb/35.203
抄録	Studies on drug disposition in inflamed skin are important for safe and effective application of topical drugs. Here, the absorption of flurbiprofen (FP) through inflamed skin was examined in vivo and in a skin-mimicking artificial model system. The model skin system consisted of a silicone membrane acting as a model stratum corneum, laminated dialysis membranes acting as a model of viable skin, and 2 microdialysis probes?one used for determination of FP concentration and one acting as a model vessel. This model system could be used for quantitative evaluation of complicated permeation processes. In the in vivo experiments, FP absorption was suppressed in rats with inflamed skin induced by an intracutaneous injection of a mixed solution of λ-carrageenan, zymosan, and casein. Bovine serum albumin solution was placed between the dialysis membranes in the model skin system to mimic protein leaching in skin; the results suggested that the delayed absorption of FP in inflamed skin was due to binding to serum proteins leaching in the tissue. Such a combination of in vivo experiments and a model skin system is useful for understanding complex phenomena in inflamed and damaged skin and reduces experimental animal use.
キーワード	skin absorption/model skin system/inflamed skin/protein binding/flurbiprofen
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
このアイテムを表示する：本文(pdf)	( 799.3KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.35.203

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