城西大学機関リポジトリJURAEvaluation of the Effects of Absorption Enhancers on Caco-2 Cell Monolayers by Using a Pore Permeation Model Involving Two Different Sizes

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Evaluation of the Effects of Absorption Enhancers on Caco-2 Cell Monolayers by Using a Pore Permeation Model Involving Two Different Sizes

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ID	JOS-bpb.b13-00471
著者：名前	関, 俊暢/濱田, 愛里/江川, 祐哉/八巻, 努/内田, 昌希/夏目, 秀視/木村, 聡一郎/上田, 秀雄
著者：別形式	Seki, Toshinobu / Hamada, Airi / Egawa, Yuya / Yamaki, Tsutomu / Uchida, Masaki / Natsume, Hideshi / Kimura, Soichiro / Ueda, Hideo
著者：カナ	セキ, トシノブ/ハマダ, アイリ/エガワ, ユウヤ/ヤマキ, ツトム/ウチダ, マサキ/ナツメ, ヒデシ/キムラ, ソウイチロウ/ウエダ, ヒデオ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 /城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences /Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	36
号	11
刊行年月	2013-11
開始ページ	1862
終了ページ	1866
コンテンツ作成日	2013-08-11
コンテンツ登録日	2014-01-29
識別番号：DOI	info:doi/10.1248/bpb.b13-00471
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.b13-00471
医中誌ID	2014184071
識別番号：その他	JOI:DN/JST.JSTAGE/bpb/b13-00471
抄録	We applied a parallel pore permeation model based on the Renkin molecular sieving function by using two different-sized pathways to analyze the permeation-enhancing effects of poly-L-arginine (PLA) or a mixed system of spermine (SPM) and sodium taurocholate (STC). Four paracellular markers were simultaneously applied to Caco-2 cell monolayers, and a set of apparent permeability coefficient (P) values was used to obtain membrane parameters. For PLA treatment, the pore occupancy/length ratio (ε/L) of the large pathways increased while the pore radius (R) did not, suggesting that the number of large pathways for the relatively large hydrophilic molecules in the monolayers could be increased by the addition of PLA. In contrast, application of the mixed system comprising SPM and STC significantly increased not only the R of the large pathways but also ε/L of the small pathways. Such changes in membrane parameters could be related to the enhancing mechanism of these compounds. The simulation curves for molecular weight (MW)-P calculated from the membrane parameters could be used to predict the P of drugs with different MWs.
キーワード	permeation enhancer/Caco-2 cell/poly-L-arginine/spermine/sodium taurocholate/Renkin function
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c 2013 The Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 467.1KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b13-00471

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