城西大学機関リポジトリJURAL-Ascorbic Acid- and L-Ascorbic Acid 2-Glucoside Accelerate in Vivo Liver Regeneration and Lower Serum Alanine Aminotransaminase Activity in 70% Partially Hepatectomized Rats

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L-Ascorbic Acid- and L-Ascorbic Acid 2-Glucoside Accelerate in Vivo Liver Regeneration and Lower Serum Alanine Aminotransaminase Activity in 70% Partially Hepatectomized Rats

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ID	JOS-bpb.b13-00839
著者：名前	木村, 光利/茂木, 肇/内田, 昌希/夏目, 秀視/荻原, 政彦
著者：別形式	Kimura, Mitsutoshi / Moteki, Hajime / Uchida, Masaki / Natsume, Hideshi / Ogihara, Masahiko
著者：カナ	キムラ, ミツトシ/モテキ, ハジメ/ウチダ, マサキ/ナツメ, ヒデシ/オギハラ, マサヒコ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Science, Department of Clinical Pharmacology / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Pharmacology / Josai University, Faculty of Pharmaceutical Science, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Science, Department of Pharmaceutics / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Pharmacology
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	37
号	4
刊行年月	2014-04
開始ページ	597
終了ページ	603
コンテンツ作成日	2014-02-07
コンテンツ登録日	2014-07-02
識別番号：DOI	info:doi/10.1248/bpb.b13-00839
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.b13-00839
識別番号：その他	JOI:DN/JST.JSTAGE/bpb/b13-00839
抄録	The effects of L-ascorbic acid and its stable analogue L-ascorbic acid 2-glucoside on the restoration of liver mass and recovery of liver function after 70% partial hepatectomy (PH), were compared with other natural vitamin C analogues in rats in vivo. L-Ascorbic acid (100?mg/kg/d, intraperitoneally (i.p.))- and L-ascorbic acid 2-glucoside (50?mg/kg/d, i.p.)-treated rats showed an approximately 1.3-fold increase in the ratio of liver weight (LW) to body weight (BW), when compared to saline (as control)-, L-dehydroascorbic acid (150?mg/kg/d, i.p.)- and D-isoascorbic acid (150?mg/kg/d, i.p.)-administrated rats on day 3 after PH. Accordingly, 5-bromo-2′-deoxyuridine-labeling index in the regenerating iver was significantly higher in L-ascorbic acid- and L-ascorbic acid 2-glucoside-treated rats compared with saline-, L-dehydroascorbic acid- and D-isoascorbic acid-treated rats on day 1. In control rats, liver-related serum alanine aminotransferase (ALT) activity was rapidly elevated on day 1, and then decreased to near pre-operative levels on day 5 following PH. L-Ascorbic acid and L-ascorbic acid 2-glucoside significantly lowered the serum ALT on day 1 after PH compared with saline-, L-dehydroascorbic acid- and D-isoascorbic acid-administered rats. These results demonstrate that L-ascorbic acid and L-ascorbic acid 2-glucoside significantly promote the regeneration of liver mass and function with full recovery after liver injury.
キーワード	partial hepatectomy/liver regeneration/serum alanine aminotransferase/L-ascorbic acid/L-ascorbic acid 2-glucoside
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c 2014 The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b13-00839

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