城西大学機関リポジトリJURAEffect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats

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Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats

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ID	JOS-bpb.b15-00727
著者：名前	間, 祐太朗/前川, 俊久/三木, 涼太郎/大島, 新司/江川, 祐哉/Morimoto, Kazuhiro/関, 俊暢
著者：別形式	Hazama, Yutaro / Maekawa, Toshihisa / Miki, Ryotaro / Oshima, Shinji / Egawa, Yuya / Morimoto, Kazuhiro / Seki, Toshinobu
著者：カナ	ハザマ, ユウタロウ/マエカワ, トシヒサ/ミキ, リョウタロウ/オオシマ, シンジ/エガワ, ユウヤ/モリモト, カズヒロ/セキ, トシノブ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 日本薬科大学 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Nihon Pharmaceutical University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	39
号	3
刊行年月	2016-03
開始ページ	343
終了ページ	352
コンテンツ作成日	2015-09-23
コンテンツ修正日	2015-12-06
コンテンツ登録日	2016-04-14
識別番号：DOI	info:doi/10.1248/bpb.b15-00727
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/bpb.b15-00727
抄録	Tacrolimus (TL) ointment is a topical treatment for atopic dermatitis, a disease that exhibits various skin conditions. The effect of skin pathologies on the systemic absorption of TL and related side effects remains unknown. This study aimed to investigate factors affecting the cutaneous absorption of TL. We prepared various skin models in hairless rats by tape stripping, injection of prophlogistic material solution (PMS), and continuous subcutaneous adrenaline (Adr) infusion. In vivo absorption studies were conducted, with measurements of transepidermal water loss (TEWL) and skin blood flow as physiological parameters. Very little TL absorption was observed through intact skin. Greater TL absorption was noted in skins with high TEWL values and fully stripped skin with PMS injections. In contrast, Adr infusion, which reduced skin blood flow, resulted in decreased TL absorption through fully stripped skin. Combined use of TL and Adr on skin with PMS injections resulted in suppression of TL absorption. Our results revealed that TL absorption following topical application is affected by alterations in the skin barrier, blood flow, and vascular permeability. We propose an administration plan for TL in a flowchart as a means of preventing systemic side effects.
キーワード	tacrolimus/cutaneous absorption/atopic dermatitis/inflamed skin/transepidermal water loss/skin blood flow
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c 2016 The Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 951.7KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b15-00727

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