城西大学機関リポジトリJURAPreparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

更新日：2026/10/05

件数：7,478件

TOP

Japanese

No.1(全1件)

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

このページを印刷

ID	JOS-bpb.b16-00781
著者：名前	神矢, 佑輔/八巻, 努/内田, 昌希/畑中, 朋美/木村, 光利/荻原, 政彦/森本, 雍憲/夏目, 秀視
著者：別形式	Kamiya, Yusuke / Yamaki, Tsutomu / Uchida, Masaki / Hatanaka, Tomomi / Kimura, Mitsutoshi / Ogihara, Masahiko / Morimoto, Yasunori / Natsume, Hideshi
著者：カナ	カミヤ, ユウスケ/ヤマキ, ツトム/ウチダ, マサキ/ハタナカ, トモミ/キムラ, ミツトシ/オギハラ, マサヒコ/モリモト, ヤスノリ/ナツメ, ヒデシ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 東海大学医学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Tokai University School of Medicine / Josai University, Faculty of Pharmaceutical Sciences / JJosai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	40
号	2
刊行年月	2017
開始ページ	205
終了ページ	211
コンテンツ作成日	2016-09-30
コンテンツ修正日	2016-11-23
コンテンツ登録日	2017-06-08
識別番号：DOI	info:doi/10.1248/bpb.b16-00781
識別番号：DOI（リンク）	http://doi.org/10.1248/bpb.b16-00781
抄録	Polycationic compounds, such as poly-L-arginine and poly-L-ornithine (PLO), enhance the nasal absorption of hydrophilic macromolecular drugs. However, the bio availability corresponding to the dose of these enhancers has not been obtained in an open system study, where an administered solution is transferred to the pharynx because they do not exhibit mucoadhesion/retention in the nasal cavity. In this study, we prepared PEGylated-poly-L-ornithine (PEG-PLO) and investigated the effects of PEGylation on in vitro adhesion/retention properties, permeation enhancement efficiency, and cytotoxicity. PEG-PLO bearing 3–4 polyethylene glycol (PEG) chains per PLO molecule was more retentive than unmodified PLO on an inclined plate. The permeability of a model drug, FD-4, across Caco-2 cell sheets was enhanced by PEG-PLO as well as by PLO. PLO showed cytotoxicity at high concentrations, whereas PEG-PLO did not decrease cell viability, even above the concentration giving a sufficient enhancement effect. These findings suggest that PEGylation of polycationic absorption enhancers improves their adhesion/retention and decreases their cytotoxicity, which may lead to enhancers with greater utility.
キーワード	poly-L-ornithine (PLO)/polyethylene glycol (PEG)/permeation enhancer
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2017 The Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 643.5KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b16-00781

var xurl =document.URL; var xrecid = 'G0000284repository_JOS-bpb.b16-00781'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-bpb.b16-00781"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight();