| ID | JOS-bpb.b16-00783 |
| 著者：名前 | |
| 著者：別形式 | Akimoto, Hayato / Oshima, Shinji / Ohara, Kousuke / Negishi, Akio / Hiroyama, Hanako / Nemoto, Tadashi / Kobayashi, Daisuke |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 産業技術総合研究所バイオメディカル研究部門 / 産業技術総合研究所バイオメディカル研究部門 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / National Institute of Advanced Industrial Science and Technology (AIST), Biomedical Research Institute / National Institute of Advanced Industrial Science and Technology (AIST), Biomedical Research Institute / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA10885497 |
| 冊子ISSN | 09186158 |
| 電子ISSN | 13475215 |
| 掲載誌名 | |
| 巻 | 40 |
| 号 | 6 |
| 刊行年月 | 2017 |
| 開始ページ | 789 |
| 終了ページ | 796 |
| コンテンツ作成日 | 2016-09-30 |
| コンテンツ修正日 | 2017-02-27 |
| コンテンツ登録日 | 2017-08-03 |
| 識別番号：DOI | info:doi/10.1248/bpb.b16-00783 |
| 識別番号：DOI（リンク） | |
| 抄録 | Depressive disorders cause large socioeconomic effects influencing not only the patients themselves but
also their family and broader community as well. To better understand the physiologic factors underlying
depression, in this study, we performed metabolomics analysis, an omics technique that comprehensively analyzes
small molecule metabolites in biological samples. Specifically, we utilized high-resolution magic-angle
spinning-1H-NMR (HRMAS-1H-NMR) spectroscopy to comprehensively analyze the changes in metabolites
in the hippocampal tissue of rats exposed to chronic stress (CS) via multi-step principal component analysis
(multi-step PCA). The rats subjected to CS exhibited obvious depression-like behaviors. High correlations
were observed between the first principal component (PC1) score in the score plot obtained using multi-step
PCA and measurements from depression-like behavioral testing (body weight, sucrose preference test, and
open field test). Alanine, glutamate, glutamine, and aspartate levels in the hippocampal tissue were significantly
lower, whereas N-acetylaspartate, myo-inositol, and creatine were significantly higher in the CS group
compared to the control (non-CS) group. As alanine, glutamate, and glutamine are known to be involved
in energy metabolism, especially in the tricarboxylic acid cycle, chronic exogenous stress may have induced
abnormalities in energy metabolism in the brains of the rats. The results suggest that N-acetylaspartate and
creatine levels may have increased in order to complement the loss of energy-producing activity resulting
from the development of the depression-like disorder. Multi-step PCA therefore allowed an exploration of the
degree of depression-like symptoms as represented by changes in intrinsic metabolites. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 The Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 707.0KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
