城西大学機関リポジトリJURAMetabolic Profiling of the Hippocampus of Rats Experiencing Nicotine-Withdrawal Symptoms

更新日：2025/12/02

件数：7,287件

TOP

Japanese

No.1(全1件)

Metabolic Profiling of the Hippocampus of Rats Experiencing Nicotine-Withdrawal Symptoms

このページを印刷

ID	JOS-bpb.b18-00486
著者：名前	秋元, 勇人/大島, 新司/道山, 雄一/根岸, 彰生/Nemoto, Tadashi/小林, 大介
著者：別形式	Akimoto, Hayato / Oshima, Shinji / Michiyama, Yuichi / Negishi, Akio / Nemoto, Tadashi / Kobayashi, Daisuke
著者：カナ	アキモト, ハヤト/オオシマ, シンジ/ミチヤマ, ユウイチ/ネギシ, アキオ/ネモト, タダシ/コバヤシ, ダイスケ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 産業技術総合研究所バイオメディカル研究部門 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / National Institute of Advanced Industrial Science and Technology (AIST) , Biomedical Research Institute / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	41
号	12
刊行年月	2018-12
開始ページ	1879
終了ページ	1884
コンテンツ作成日	2018-06-26
コンテンツ修正日	2018-09-17
コンテンツ登録日	2019-04-18
識別番号：DOI	info:doi/10.1248/bpb.b18-00486
識別番号：DOI（リンク）	https://doi.org/10.1248/bpb.b18-00486
NII論文ID	130007539561
抄録	Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric events, such as depression and suicide, during use of smoking-cessation drugs. We aimed to investigate whether the results of the metabolomic analysis of the rat brain reflect nicotine-withdrawal symptoms. We also aimed to investigate the relative changes in each metabolite in the brains of rats with nicotine-withdrawal symptoms. We created rats experiencing nicotine-withdrawal symptoms through repeat administration of nicotine followed by a 12-h withdrawal period, and rats recovered from nicotine-withdrawal symptoms followed by an 18-h withdrawal period. We then implemented brain metabolic profiling by combining high-resolution magic-angle spinning 1H-NMR spectroscopy with partial least square discriminant analysis (PLS-DA). We found that metabolic profiling of the brain reflects the state during nicotine-withdrawal symptoms and the state after recovery from nicotine-withdrawal symptoms. Additionally, N-acetylaspartate and glutamate increased and aspartate, γ-aminobutyric acid (GABA), and creatine decreased in the hippocampus of rats experiencing nicotine-withdrawal symptoms. Therefore, it is suggested that neurogenesis and neuronal differentiation could be changed and abnormal energy metabolism could occur in the hippocampus during nicotine-withdrawal symptoms.
キーワード	nicotine-withdrawal/metabolomics/hippocampus/NMR spectroscopy/N-acetylaspartate
注記	Note
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2018 Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 1.3MB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b18-00486

var xurl =document.URL; var xrecid = 'G0000284repository_JOS-bpb.b18-00486'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-bpb.b18-00486"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight();