ID | JOS-bpb.b18-00486 |
著者:名前 | |
著者:別形式 | Akimoto, Hayato / Oshima, Shinji / Michiyama, Yuichi / Negishi, Akio / Nemoto, Tadashi / Kobayashi, Daisuke |
著者:カナ | |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 産業技術総合研究所バイオメディカル研究部門 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / National Institute of Advanced Industrial Science and Technology (AIST) , Biomedical Research Institute / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬学会 |
出版者:カナ | ニホンヤクガクカイ |
出版者:別名 | The Pharmaceutical Society of Japan |
NCID | AA10885497 |
冊子ISSN | 09186158 |
電子ISSN | 13475215 |
掲載誌名 | |
巻 | 41 |
号 | 12 |
刊行年月 | 2018-12 |
開始ページ | 1879 |
終了ページ | 1884 |
コンテンツ作成日 | 2018-06-26 |
コンテンツ修正日 | 2018-09-17 |
コンテンツ登録日 | 2019-04-18 |
識別番号:DOI | info:doi/10.1248/bpb.b18-00486 |
識別番号:DOI(リンク) | |
NII論文ID | 130007539561 |
抄録 | Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric events, such as depression and suicide, during use of smoking-cessation drugs. We aimed to investigate whether the results of the metabolomic analysis of the rat brain reflect nicotine-withdrawal symptoms. We also aimed to investigate the relative changes in each metabolite in the brains of rats with nicotine-withdrawal symptoms. We created rats experiencing nicotine-withdrawal symptoms through repeat administration of nicotine followed by a 12-h withdrawal period, and rats recovered from nicotine-withdrawal symptoms followed by an 18-h withdrawal period. We then implemented brain metabolic profiling by combining high-resolution magic-angle spinning 1H-NMR spectroscopy with partial least square discriminant analysis (PLS-DA). We found that metabolic profiling of the brain reflects the state during nicotine-withdrawal symptoms and the state after recovery from nicotine-withdrawal symptoms. Additionally, N-acetylaspartate and glutamate increased and aspartate, γ-aminobutyric acid (GABA), and creatine decreased in the hippocampus of rats experiencing nicotine-withdrawal symptoms. Therefore, it is suggested that neurogenesis and neuronal differentiation could be changed and abnormal energy metabolism could occur in the hippocampus during nicotine-withdrawal symptoms. |
キーワード | |
注記 | Note |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2018 Pharmaceutical Society of Japan |
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