城西大学機関リポジトリJURAEnhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats

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Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats

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ID	JOS-bpb.b18-00673
著者：名前	大森, 慈大/神矢, 佑輔/八巻, 努/内田, 昌希/大竹, 一男/木村, 光利/夏目, 秀視
著者：別形式	Omori, Shigehiro / Kamiya, Yusuke / Yamaki, Tsutomu / Uchida, Masaki / Kazuo, Ohtake / Kimura, Mitsutoshi / Natsume, Hideshi
著者：カナ	オオモリ, シゲヒロ/カミヤ, ユウスケ/ヤマキ, ツトム/ウチダ, マサキ/オオタケ, カズオ/キムラ, ミツトシ/ナツメ, ヒデシ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA10885497
冊子ISSN	09186158
電子ISSN	13475215
掲載誌名	Biological and Pharmaceutical Bulletin
巻	42
号	1
刊行年月	2019-01
開始ページ	144
終了ページ	148
コンテンツ作成日	2018-08-31
コンテンツ修正日	2018-10-29
コンテンツ登録日	2019-04-26
識別番号：DOI	info:doi/10.1248/bpb.b18-00673
識別番号：DOI（リンク）	https://doi.org/10.1248/bpb.b18-00673
NII論文ID	130007542235
抄録	The transnasal route for the delivery of water-soluble macromolecules, such as bioactive peptides and proteins, has attracted interest, although the use of permeation enhancers is required due to the poor permeabilities of these macromolecules across the nasal mucosa. With polycationic compounds, such as poly-L-arginine and chitosan, the nasal absorption of hydrophilic macromolecules is molecular weight- and concentration-dependently enhanced without causing cytotoxicity. In the present study, we evaluated the effect of various molecular weights and concentrations of poly-L-ornithine (PLO), a polycationic compound, on the nasal absorption and the damage to the nasal mucosa in vivo. PLO enhanced the nasal absorption of fluorescein isothiocyanate-dextran (FD-4), used as a model drug, and the bioavailability of FD-4 increased with the concentration of PLO. The enhancement effect was also dependent on the molecular weight. The administration of PLO at a concentration that sufficed for enhancing the nasal absorption had no effect on the activity of lactic dehydrogenase and the protein leakage in the nasal fluid, as indices of nasal mucosa damage. These findings suggest that a transnasal delivery system using PLO is a useful strategy for improving the nasal absorption of water-soluble macromolecules without toxicity to the nasal mucosa.
キーワード	poly-L-ornithine (PLO)/nasal absorption/enhancement effect/molecular weight
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2018 Pharmaceutical Society of Japan
このアイテムを表示する：本文(pdf)	( 443.6KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-bpb.b18-00673

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