城西大学機関リポジトリJURADecrease in Skin Permeation and Antibacterial Effect of Parabens by a Polymeric Additive, Poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)

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Decrease in Skin Permeation and Antibacterial Effect of Parabens by a Polymeric Additive, Poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)

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ID	JOS-cpb.53.271
著者：名前	長谷川, 哲也/金, 素安/Tsuchida, Mamoru/一色, 恭徳/近藤, 誠一/杉林, 堅次
著者：別形式	Hasegawa, Tetsuya / Kim, Soan / Tsuchida, Mamoru / Issiki, Yasunori / Kondo, Seiichi / Sugibayashi, Kenji
著者：カナ	ハセガワ, テツヤ/キム, ソアン/ツチダ, マモル/イッシキ, ヤスノリ/コンドウ, セイイチ/スギバヤシ, ケンジ
著者：所属	城西大学薬学部 / 城西大学薬学部 / NOF Corporation, Tsukuba Research Laboratory / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / NOF Corporation, Tsukuba Research Laboratory / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences /
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA00602100
冊子ISSN	00092363
電子ISSN	13475223
掲載誌名	Chemical and Pharmaceutical Bulletin
巻	53
号	3
刊行年月	2005
開始ページ	271
終了ページ	276
コンテンツ作成日	2004-12-11
コンテンツ登録日	2014-02-21
識別番号：DOI	info:doi/10.1248/cpb.53.271
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/cpb.53.271
識別番号：その他	JOI:JST.JSTAGE/cpb/53.271
抄録	The inhibitory effect of poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate) (PMB) on the in vitro skin permeation of p-hydroxybenzoic acid and its esters (parabens; methylparaben, ethylparaben, n-propylparaben and n-butylparaben) as model compounds was evaluated. Solubility of the parabens in distilled water was increased by addition of PMB, and the increasing ratio was dependent on the concentration of PMB. The increment of the ratio was more marked in lipophilic parabens than hydrophilic ones. Skin permeability of parabens from their aqueous suspensions was decreased by addition of PMB, and the decreasing ratio was dependent on the PMB concentration. Then, antibacterial effect of parabens of their aqueous solutions was determined with and without PMB by measuring minimum inhibitory concentration (MIC) against E. coli and S. aureus. As results, MIC and antibacterial effect were increased and decreased, respectively, by addition of PMB. The contribution of PMB was more marked in butylparaben than methylparaben. These decreases in skin permeation and antibacterial effect of parabens by PMB are probably due to a higher solubility in water and a lower partition to the skin and bacterial membranes of parabens by addition of PMB.
キーワード	skin permeation/polymeric additive/paraben/antibacterial effect/poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright ? 2005 The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-cpb.53.271

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