城西大学機関リポジトリJURAA Novel Preparation Method for Microspheres of Water Soluble Polymers Using Polypropyleneglycol as the Dispersion Medium

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A Novel Preparation Method for Microspheres of Water Soluble Polymers Using Polypropyleneglycol as the Dispersion Medium

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ID	JOS-cpb.55.403
著者：名前	関, 俊暢/篠原, 克典/加藤, 奈穂子/内田, 昌希/夏目, 秀視/Morimoto, Kazuhiro/從二, 和彦
著者：別形式	Seki, Toshinobu / Shinohara, Katsunori / Kato, Naoko / Uchida, Masaki / Natsume, Hideshi / Morimoto, Kazuhiro / Juni, Kazuhiko
著者：カナ	セキ, トシノブ/シノハラ, カツノリ/カトウ, ナオコ/ウチダ, マサキ/ナツメ, ヒデシ/モリモト, カズヒロ/ジュウニ, カズヒコ
著者：所属	北海道薬科大学 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 北海道薬科大学 / 城西大学薬学部 /
著者：所属(別形式）	Hokkaido Pharmaceutical University School of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Hokkaido Pharmaceutical University School of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences /
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA00602100
冊子ISSN	00092363
電子ISSN	13475223
掲載誌名	Chemical and Pharmaceutical Bulletin
巻	55
号	3
刊行年月	2007-03
開始ページ	403
終了ページ	406
コンテンツ作成日	2006-12-22
コンテンツ登録日	2014-03-20
識別番号：DOI	info:doi/10.1248/cpb.55.403
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/cpb.55.403
識別番号：その他	JOI:JST.JSTAGE/cpb/55.403
抄録	Polypropyleneglycol (PPG) was used as a dispersion medium for the preparation of microspheres (MS) consisting of starch, gelatin, whey protein or dextran. Aqueous solutions of the polymers were dispersed in PPG at various initial temperatures and then the systems were cooled to 0.5 °C to allow water in the dispersed phase to dissolve in PPG. The particle size of the starch-MS was dependent on the initial temperature of PPG in the preparation process. There were two different processes for particle generation in the procedure. One of them was via the formation of a temporary emulsion during the early phase of dispersion of the aqueous polymer solution into PPG. The other was via the stable emulsion in which the aqueous polymer solution was dispersed in water-saturated PPG. The particle size generated in the former process was dependent on the initial temperature: a high temperature gave large particles but a low temperature gave small particles, while that in the latter process was temperature-independent. This preparation method for MS will be useful for the formulation of heat-sensitive material, such as protein-containing drugs.
キーワード	microsphere/polypropyleneglycol/starch/gelatin/whey protein/dextran
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-cpb.55.403

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