城西大学機関リポジトリJURAMolecular states of p-dimethylaminobenzonitrile coground with β-cyclodextrin investigated using solid-state fluorescence spectroscopy

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Molecular states of p-dimethylaminobenzonitrile coground with β-cyclodextrin investigated using solid-state fluorescence spectroscopy

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ID	JOS-cpb.59.1299
著者：名前	井上, 裕/Hasegawa, Nana/Tozuka, Yuichi/米持, 悦生/小口, 敏夫/東, 顕二郎/森部, 久仁一/山本, 恵司
著者：別形式	Inoue, Yutaka / Hasegawa, Nana / Tozuka, Yuichi / Yonemochi, Etsuo / Oguchi, Toshio / Higashi, Kenjirou / Moribe, Kunikazu / Yamamoto, Keiji
著者：カナ	イノウエ, ユタカ/ハセガワ, ナナ/トヅカ, ユウイチ/ヨネモチ, エツオ/オグチ, トシオ/ヒガシ, ケンジロウ/モリベ, クニカズ/ヤマモト, ケイジ
著者：所属	城西大学薬学部医薬品安全性学講座 / 千葉大学大学院薬学研究院 / 岐阜薬科大学 / 東邦大学薬学部薬剤学教室 / 山梨大学医学部付属病院 / 千葉大学大学院薬学研究院 / 千葉大学大学院薬学研究院 / 千葉大学大学院薬学研究院
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Chiba University, Graduate School of Pharmaceutical Sciences / Gifu Pharmaceutical University, Laboratory of Pharmaceutical Engineering / Toho University, School of Pharmaceutical Sciences, Department of Pharmaceutics / University of Yamanashi Hospital, Department of Pharmacy / Chiba University, Graduate School of Pharmaceutical Sciences / Chiba University, Graduate School of Pharmaceutical Sciences, / Chiba University, Graduate School of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA00602100
冊子ISSN	00092363
電子ISSN	13475223
掲載誌名	Chemical and Pharmaceutical Bulletin
巻	59
号	10
刊行年月	2011
開始ページ	1299
終了ページ	1302
コンテンツ作成日	2011-07-06
コンテンツ登録日	2013-10-28
識別番号：DOI	info:doi/10.1248/cpb.59.1299
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/cpb.59.1299
識別番号：その他	JOI:JST.JSTAGE/cpb/59.1299
抄録	Changes in molecular states of p-dimethylaminobenzonitrile (DMABN) coground with β-cyclodextrin (β-CD) were examined using solid-state fluorescence measurements. Formation of a DMABN/β-CD inclusion complex by coprecipitation was confirmed by powder X-ray diffraction measurement. The powder X-ray diffraction pattern of the ground mixture was a halo pattern and differed from the pattern of the mixture prepared by coprecipitation. Solid-state fluorescence measurements revealed emission by DMABN crystals in a twisted intermolecular charge-transfer state at 473 nm. DMABN in the DMABN/β-CD coprecipitate had a fluorescence emission peak at 393 nm due to its planar structure. In contrast, DMABN in a DMABN/β-CD ground mixture had an emission peak at 473 nm due to its twisted structure. Grinding time-dependent structural changes in DMABN were evaluated using fluorescence lifetime and relative quantum yield measurements. Structural changes in DMABN in the DMABN/β-CD coprecipitate from a planar to a twisted structure were observed with grinding. DMABN, dispersed in microcrystalline cellulose (CC) molecules in a DMABN/CC ground mixture, had a fluorescence emission peak at 473 nm. However, the excitation spectrum of a DMABN/β-CD ground mixture differed from that of DMABN in CC. These results indicated that the molecular state of DMABN accommodated in the β-CD cavity differs between the coprecipitate and the ground mixture.
キーワード	solid-state fluorescence/p-dimethylaminobenzonitrile/β-cyclodextrin/ground mixture/coprecipitate
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-cpb.59.1299

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