城西大学機関リポジトリJURAPreparation of Polypseudorotaxanes Composed of Cyclodextrin and Polymers in Microspheres

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Preparation of Polypseudorotaxanes Composed of Cyclodextrin and Polymers in Microspheres

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ID	JOS-cpb.62_c14-00313
著者：名前	篠原, 克典/Yamashita, Miki/内田, 亘/岡部, 千恵/大島, 新司/杉野, 雅浩/江川, 祐哉/三木, 涼太郎/細谷, 治/Fujihara, Takashi/Ishimaru, Yoshihiro/Kishino, Tohru/関, 俊暢/從二, 和彦
著者：別形式	Shinohara, Katsunori / Yamashita, Miki / Uchida, Wataru / Okabe, Chie / Oshima, Shinji / Sugino, Masahiro / Egawa, Yuya / Miki, Ryotaro / Hosoya, Osamu / Fujihara, Takashi / Ishimaru, Yoshihiro / Kishino, Tohru / Seki, Toshinobu / Juni, Kazuhiko
著者：カナ	シノハラ, カツノリ/ヤマシタ, ミキ/ウチダ, ワタル/オカベ, チエ/オオシマ, シンジ/スギノ, マサヒロ/エガワ, ユウヤ/ミキ, リョウタロウ/ホソヤ, オサム/フジハラ, タカシ/イシマル, ヨシヒロ/キシノ, トオル/セキ, トシノブ/ジュウニ, カズヒコ
著者：所属	埼玉医科大学 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 埼玉大学 / 埼玉大学 / 埼玉医科大学 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Saitama Medical University, Saitama Medical Center, Department of Pharmacy Services / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Saitama University, Comprehensive Analysis Center for Science, Research and Development Bureau / Saitama University, Graduate School of Science and Engineering, Division of Material Science / Saitama Medical University, Saitama Medical Center, Department of Pharmacy Services / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA00602100
冊子ISSN	00092363
電子ISSN	13475223
掲載誌名	Chemical and Pharmaceutical Bulletin
巻	62
号	10
刊行年月	2014-10
開始ページ	962
終了ページ	966
コンテンツ作成日	2014-03-11
コンテンツ登録日	2014-11-08
識別番号：DOI	info:doi/10.1248/cpb.c14-00313
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/cpb.c14-00313
識別番号：その他	JOI:DN/JST.JSTAGE/cpb/c14-00313
抄録	We prepared polypseudorotaxanes (PPRXs) composed of cyclodextrin (CyD) and polyethylene glycol (PEG) inside microspheres (MSs) by an emulsifying process using polypropylene glycol (PPG) that shows temperature-dependent hydrophilicity changes; PPG is hydrophobic at high temperatures but hydrophilic at low temperatures. An aqueous solution of CyD and PEG was dispersed as droplets in PPG at 60°C then cooled to 0°C to allow water of droplets to transfer into PPG. On removal of water in the droplets, CyD and PEG were left behind as a CyD/PEG PPRX inside the solid-state MSs. Examination of α-, β-, and γ-CyD revealed that α-CyD was suitable for the formation of PPRX containing PEG in this MS preparation procedure. Interestingly, a new PPRX composed of α-CyD and PPG was formed in the α-CyD MSs when they were prepared in the absence of PEG from the aqueous solution of α-CyD. This MS fabrication procedure can control the size and shape of PPRX particles, and will contribute to the production of new types of CyD inclusion complexes.
キーワード	cyclodextrin (CyD)/microsphere (MS)/polyethylene glycol (PEG)/polypropylene glycol (PPG)/polypseudorotaxane (PPRX)
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright c2014 The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-cpb.62_c14-00313

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