城西大学機関リポジトリJURAStudy of Complex Formation of Carbamazepine with Thiourea

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Study of Complex Formation of Carbamazepine with Thiourea

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ID	JOS-cpb.c14-00340
著者：名前	井上, 裕/佐藤, 彩友里/山本, 千砂/Yamasaki, Mikio/金本, 郁男
著者：別形式	Inoue, Yutaka / Sato, Sayuri / Yamamoto, Chisa / Yamasaki, Mikio / Kanamoto, Ikuo
著者：カナ	イノウエ, ユタカ/サトウ, サユリ/ヤマモト, チサ/ヤマサキ, ミキオ/カナモト, イクオ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 株式会社リガク / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Safety Management / Rigaku Corporation / Josai University, Faculty of Pharmaceutical Sciences, Department of Drug Safety Management
著者版フラグ	publisher
出版地	東京
出版者	日本薬学会
出版者：カナ	ニホンヤクガクカイ
出版者：別名	The Pharmaceutical Society of Japan
NCID	AA00602100
冊子ISSN	00092363
電子ISSN	13475223
掲載誌名	Chemical and Pharmaceutical Bulletin
巻	62
号	11
刊行年月	2014-11
開始ページ	1125
終了ページ	1130
コンテンツ作成日	2014-04-26
コンテンツ修正日	2014-08-23
コンテンツ登録日	2015-01-18
識別番号：DOI	info:doi/10.1248/cpb.c14-00340
識別番号：DOI（リンク）	http://dx.doi.org/10.1248/cpb.c14-00340
抄録	The aim of this study, we evaluated a complex between thiourea (TU) and carbamazepine (CBZ) of a poorly soluble drug by using powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR) spectroscopy, X-ray crystallography and the solubility test. PXRD of TU/CBZ=2/1, 1/1, and 1/2 prepared by solvent evaporation (EVP) revealed characteristic diffraction peaks at 2θ=6.7°, 8.8°, 13.5°, and 20.4°, therefore molecular interaction between TU and CBZ presumably occurred. Results of the FT-IR spectroscopy, asymmetric and symmetric NH stretching vibration of TU were shifted to high region by TU/CBZ=2/1, 1/1, and 1/2 EVP. TU/CBZ=2/1 and 1/1 EVP had absorption derived from TU. It was considered that complex were formed by TU/CBZ=1/2. X-Ray crystallography of TU and CBZ revealed a crystal structure with one TU molecule arranged near two CBZ molecules. Molecules of the same type overlap in this layer. When doing a solubility test by using CBZ and samples of EVP, physical mixture and crystals in TU/CBZ=1/2 to confirm the solubility in water of TU/CBZ complex, there is no difference with the CBZ. It considered that the structure of a complex differs from the tunnel structure of inclusion complexes that has been previously reported contribute to result it.
キーワード	thiourea/carbamazepine/complex/X-ray crystallography/hydrogen bond
注記	Released on J-STAGE 20141101
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	c2014 The Pharmaceutical Society of Japan
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このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-cpb.c14-00340

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