| ID | JOS-cpb.c14-00881 |
| 著者:名前 | |
| 著者:別形式 | Takao, Koichi / Noguchi, Kaori / Hashimoto, Yosuke / Shirahata, Akira / Sugita, Yoshiaki |
| 著者:カナ | |
| 著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical / Josai University, Faculty of Pharmaceutical |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者:カナ | ニホンヤクガクカイ |
| 出版者:別名 | The Pharmaceutical Society of Japan |
| NCID | AA00602100 |
| 冊子ISSN | 00092363 |
| 電子ISSN | 13475223 |
| 掲載誌名 | |
| 巻 | 63 |
| 号 | 4 |
| 刊行年月 | 2015-04 |
| 開始ページ | 278 |
| 終了ページ | 285 |
| コンテンツ作成日 | 2014-12-24 |
| コンテンツ修正日 | 2015-01-30 |
| コンテンツ登録日 | 2015-07-23 |
| 識別番号:DOI | info:doi/10.1248/cpb.c14-00881 |
| 識別番号:DOI(リンク) | |
| 抄録 | A series of fatty acid amides were synthesized and their peroxisome proliferator-activated receptor α (PPAR-α) agonistic activities were evaluated in a normal rat liver cell line, clone 9. The mRNAs of the PPAR-α downstream genes, carnitine-palmitoyltransferase-1 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase, were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR) as PPAR-α agonistic activities. We prepared nine oleic acid amides. Their PPAR-α agonistic activities were, in decreasing order, N-oleoylhistamine (OLHA), N-oleoylglycine, Oleamide, N-oleoyltyramine, N-oleoylsertonin, and Olvanil. The highest activity was found with OLHA. We prepared and evaluated nine N-acylhistamines (N-acyl-HAs). Of these, OLHA, C16:0-HA, and C18:1Δ9-trans-HA showed similar activity. Activity due to the different chain length of the saturated fatty acid peaked at C16:0-HA. The PPAR-α antagonist, GW6471, inhibited the induction of the PPAR-α downstream genes by OLHA and N-oleoylethanolamide (OEA). These data suggest that N-acyl-HAs could be considered new PPAR-α agonists. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c2015 The Pharmaceutical Society of Japan |
| このアイテムを表示する:本文(pdf) |  ( 742.6KB) ダウンロード回数: 回 |
| このアイテムを表示する:URI | |