| ID | JOS-cpb.c16-00322 |
| 著者：名前 | |
| 著者：別形式 | Uchida, Takashi / Yakumaru, Masafumi / Nishioka, Keisuke / Higashi, Yoshihiro / Sano, Tomohiko / Todo, Hiroaki / Sugibayashi, Kenji |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 花王株式会社スキンケア研究所 / 花王株式会社解析科学研究所 / 花王株式会社解析科学研究所 / 花王株式会社スキンケア研究所 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Kao Corporation, Skin Care Products Research / Kao Corporation, Analytical Science Research / Kao Corporation, Analytical Science Research / Kao Corporation, Skin Care Products Research / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA00602100 |
| 冊子ISSN | 00092363 |
| 電子ISSN | 13475223 |
| 掲載誌名 | |
| 巻 | 64 |
| 号 | 9 |
| 刊行年月 | 2016 |
| 開始ページ | 1338 |
| 終了ページ | 1346 |
| コンテンツ作成日 | 2016-04-09 |
| コンテンツ修正日 | 2016-05-29 |
| コンテンツ登録日 | 2017-10-23 |
| 識別番号：DOI | info:doi/10.1248/cpb.c16-00322 |
| 識別番号：DOI（リンク） | |
| 抄録 | We evaluated the effectiveness of a silicone membrane as an alternative to human skin using the skin permeation parameters of chemical compounds. An in vitro permeation study using 15 model compounds was conducted, and permeation parameters comprising permeability coefficient (P), diffusion parameter (DL−2), and partition parameter (KL) were calculated from each permeation profile. Significant correlations were obtained in log P, log DL−2, and log KL values between the silicone membrane and human skin. DL−2 values of model compounds, except flurbiprofen, in the silicone membrane were independent of the lipophilicity of the model compounds and were 100-fold higher than those in human skin. For antipyrine and caffeine, which are hydrophilic, KL values in the silicone membrane were 100-fold lower than those in human skin, and P values, calculated as the product of a DL−2 and KL, were similar. For lipophilic compounds, such as n-butyl paraben and flurbiprofen, KL values for silicone were similar to or 10-fold higher than those in human skin, and P values for silicone were 100-fold higher than those in human skin. Furthermore, for amphiphilic compounds with log Ko/w values from 0.5 to 3.5, KL values in the silicone membrane were 10-fold lower than those in human skin, and P values for silicone were 10-fold higher than those in human skin. The silicone membrane was useful as a human skin alternative in an in vitro skin permeation study. However, depending on the lipophilicity of the model compounds, some parameters may be over- or underestimated. |
| キーワード | |
| 注記 | Regular Article |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 The Pharmaceutical Society of Japan |
| このアイテムを表示する：本文(pdf) |  ( 857.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
