| ID | JOS-cpb.c16-00327 |
| 著者:名前 | |
| 著者:別形式 | Takao, Koichi / Yamashita, Marimo / Yashiro, Aruki / Sugita, Yoshiaki |
| 著者:カナ | |
| 著者:所属 | 城西大学薬学部薬科学科生物有機化学研究室 / 城西大学薬学部薬科学科生物有機化学研究室 / 城西大学薬学部薬科学科生物有機化学研究室 / 城西大学薬学部薬科学科生物有機化学研究室 |
| 著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Health Sciences, Laboratory of Bioorganic Chemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Health Sciences, Laboratory of Bioorganic Chemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Health Sciences, Laboratory of Bioorganic Chemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Health Sciences, Laboratory of Bioorganic Chemistry |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者:カナ | ニホンヤクガクカイ |
| 出版者:別名 | The Pharmaceutical Society of Japan |
| NCID | AA00602100 |
| 冊子ISSN | 00092363 |
| 電子ISSN | 13475223 |
| 掲載誌名 | |
| 巻 | 64 |
| 号 | 8 |
| 刊行年月 | 2016-08 |
| 開始ページ | 1203 |
| 終了ページ | 1207 |
| コンテンツ作成日 | 2016-04-11 |
| コンテンツ修正日 | 2016-04-25 |
| コンテンツ登録日 | 2017-01-27 |
| 識別番号:DOI | info:doi/10.1248/cpb.c16-00327 |
| 識別番号:DOI(リンク) | |
| 抄録 | A series of 3-benzylidene-4-chromanone derivatives (3–20) were synthesized and the structure–activity relationships for antioxidant and α-glucosidase inhibitory activities were evaluated. Among synthesized compounds, compounds 5, 13, 18, which contain catechol moiety, showed the potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (5: EC50 13 µM; 13: EC50 14 µM; 18: EC50 13 µM). The compounds 12, 14, 18 showed higher α-glucosidase inhibitory activity (12: IC50 15 µM; 14: IC50 25 µM; 18: IC50 28 µM). The compound 18 showed both of potent DPPH radical scavenging and α-glucosidase inhibitory activities. These data suggest that 3-benzylidene-4-chromanone derivatives, such as compound 18, may serve as the lead compound for the development of novel α-glucosidase inhibitors with antioxidant activity. |
| キーワード | |
| 注記 | Regular Articles |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c 2016 The Pharmaceutical Society of Japan |
| このアイテムを表示する:本文(pdf) |  ( 393.9KB) ダウンロード回数: 回 |
| このアイテムを表示する:URI | |