| ID | JOS-dds.15.121 |
| タイトル：カナ | エタノールのヘアレスラット皮膚透過と皮膚毛細血管血色素漏出性およびモルヒネ皮膚透過性の関係 |
| 別タイトル | Relationship among permeation of ethanol, leaching of hemoglobin from capillary blood, and permeation of morphine hydrochloride in hairless rat skin |
| 著者：名前 | |
| 著者：別形式 | Seki, Toshinobu / Wada, Yoshio / Kobayashi, Nobuko / Juni, Kazuhiko / Morimoto, Yasunori |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 株式会社TTS技術研究所 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences / Research Institute of TTS Technology / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | 川崎 |
| 出版者 | 日本DDS学会 |
| 出版者：カナ | ニホンDDSガッカイ |
| 出版者：別名 | The Japan Society of Drug Delivery System |
| NCID | AN10084591 |
| 冊子ISSN | 09135006 |
| 電子ISSN | 18812732 |
| 掲載誌名 | |
| 巻 | 15 |
| 号 | 2 |
| 刊行年月 | 2000 |
| 開始ページ | 121 |
| 終了ページ | 126 |
| コンテンツ作成日 | 2000 |
| コンテンツ登録日 | 2014-03-20 |
| 識別番号：DOI | info:doi/10.2745/dds.15.121 |
| 識別番号：DOI（リンク） | |
| 識別番号：その他 | JOI:JST.Journalarchive/dds1986/15.121 |
| 抄録 | Relationship between permeation of ethanol and leaching of hemoglobin from capillary blood, as a possible index of skin irritancy, was examined in hairless rats. Ethanol solutions were applied in vivo on the abdominal skin for 5h and then content of Fe, instead of hemoglobin, in the application site was measured. Permeation of ethanol through the skin was examined in vitro in the corresponding condition. The index, i. e. Fe content in the skin, shows correlation with cumulative amount of ethanol permeated or maximum flux of ethanol through the skin, while that wasn't correlated with concentration and content of ethanol in the applied solution. Since a slow and continuous permeation of ethanol for 8h didn't damage the skin, the maximum flux is more important parameter for the effect of ethanol on the skin irritation than the cumulative amount of ethanol permeated. Relationship between permeation of ethanol and morphine hydrochloride (MPH) was also examined. The cumulative amount of MPH was correlated with the maximum flux of ethanol. A formulation containing ethanol should be designed carefully so as to attain effective skin permeation of drug while avoiding the occurrence of skin irritation. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c 日本DDS学会 |
| このアイテムを表示する：本文(pdf) |  ( 1.1MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
