| ID | JOS-dds.4.121 |
| タイトル：カナ | ジリョク ニヨル ウロキナーゼ ノ ターゲティング |
| 別タイトル | Targeting of urokinase by magnetic force |
| 著者：名前 | |
| 著者：別形式 | Yoshimoto, Takayuki / Saito, Yuji / Sugibayashi, Kenji / Morimoto, Yasunori / Tsukada, Toshiyasu / Kanmatsuse, Katsuo / Kodera, Yoh / Matsushima, Ayako / Inada, Yuji |
| 著者：カナ | |
| 著者：所属 | 東京工業大学理学部生体機構学科 / 東京工業大学理学部生体機構学科 / 城西大学薬学部製剤学教室 / 城西大学薬学部製剤学教室 / 虎の門病院血液学科. 沖中記念成人病研究所 / 日本大学医学部駿河台病院循環器科 / 桐蔭学園横浜大学工学部材料工学科 / 桐蔭学園横浜大学工学部材料工学科 / 桐蔭学園横浜大学工学部材料工学科 |
| 著者：所属(別形式） | Tokyo lnstitute of Technology, Department of Biological Sciences / Tokyo lnstitute of Technology, Department of Biological Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Toranomon Hospital, Division of Hematologic Research. Okinaka Memorial Institute of Medical Research / Nihon University School of Medicine, Department of Cardiology / Toin University of Yokohama, Depatment of Materials Science and Technology / Toin University of Yokohama, Depatment of Materials Science and Technology / Toin University of Yokohama, Depatment of Materials Science and Technology |
| 著者版フラグ | publisher |
| 出版地 | 川崎 |
| 出版者 | 日本DDS学会 |
| 出版者：カナ | ニホンDDSガッカイ |
| 出版者：別名 | The Japan Society of Drug Delivery System |
| NCID | AN10084591 |
| 冊子ISSN | 09135006 |
| 電子ISSN | 18812732 |
| 掲載誌名 | |
| 巻 | 4 |
| 号 | 2 |
| 刊行年月 | 1989-03 |
| 開始ページ | 121 |
| 終了ページ | 122 |
| コンテンツ作成日 | 1989-03 |
| コンテンツ修正日 | 2009-02-23 |
| コンテンツ登録日 | 2015-08-26 |
| 識別番号：DOI | info:doi/10.2745/dds.4.121 |
| 識別番号：DOI（リンク） | |
| 抄録 | In vivo targeting of urokinase by magnetic force was examined in mice, Urokinase was labeled with 125I and was further conjugated with magnetite through a polyethylene glycol derivative. The magnetic urokinase was injected into the tip part of a tail vein of a mouse, while magnetic force (0?12000 G) was applied to the root part of the tail as a target site. The distribution of radioactivity among various parts of a mouse was measured after the animal was sacrificed. By magnetic force of 12000 G, approximately as much as 60% of magnetic urokinase injected were localized in the target, the tail root. By applying magnetic force of 12000 G to the heart, approximately 20% of magnetic urokinase injected were attracted in the heart. There was almost no retention of magnetic urokinase in the tail root when the magnetic force of 12000 G was applied even 10 sec after the injection of the magnetic urokinase. It seems that if the magnetic urokinase misses the chance to be attracted by magnetic force and passes through the lung and the liver, it is readily trapped there. It is possible that magnetic urokinase might be used for targeting in the future. |
| キーワード | |
| 言語 | jpn |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c 日本DDS学会 |
| このアイテムを表示する：本文(pdf) |  ( 449.5KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
