| ID | JOS-fts.4.179 |
| 著者：名前 | 川畑, 公平/ 玉城, 寿々香/ 小久保, 映里/ 小林, 由香里/ 篠原, 智哉/ 酒井, 絢子/ 河合, 洋/ 光本, 篤史/ 川嶋, 洋一/ 工藤, なをみ |
| 著者：別形式 | Kawabata, Kohei / Tamaki, Suzuka / Kokubo, Eri / Kobayashi, Yukari / Shinohara, Tomoya / Sakai, Ayako / Kawai, Hiroshi / Mitsumoto, Atsushi / Kawashima, Yoichi / Kudo, Naomi |
| 著者：カナ | カワバタ, コウヘイ/ タマキ, スズカ/ コクボ, エリ/ コバヤシ, ユカリ/ シノハラ, トモヤ/ サカイ, アヤコ/ カワイ, ヒロシ/ ミツモト, アツシ/ カワシマ, ヨウイチ/ クドウ, ナオミ |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Nutritional Toxicology and Applied Pharmacology |
| 著者版フラグ | publisher |
| 出版地 | Tokyo |
| 出版者 | 日本毒性学会 |
| 出版者：カナ | ニホンドクセイガッカイ |
| 出版者：別名 | The Japanese Society of Toxicology |
| 電子ISSN | 2189115X |
| 掲載誌名 | |
| 巻 | 4 |
| 号 | 4 |
| 刊行年月 | 2017 |
| 開始ページ | 179 |
| 終了ページ | 186 |
| コンテンツ作成日 | 2017-06-21 |
| コンテンツ修正日 | 2017-06-29 |
| コンテンツ登録日 | 2018-02-19 |
| 識別番号：DOI | info:doi/10.2131/fts.4.179 |
| 識別番号：DOI（リンク） | |
| NII論文ID | 130005815353 |
| 抄録 | The disposition of perfluorododecanoic acid (PFDoA), a perfluorocarboxylic acid with 12 carbon atoms, was studied in male rats. Rats received an oral administration of PFDoA at a dose of 50 mg/kg. The body weights of PFDoA-treated rats were slightly less than those of vehicle-treated control rats. PFDoA administration resulted in an increase in liver weight; it was highest at 5 days after the treatment and gradually decreased thereafter. Higher liver weight was observed until 70 days after the treatment. Concentrations of PFDoA in plasma and various tissues were estimated up to 70 days after dosing. A large amount of PFDoA was found in the liver. The PFDoA concentration was 263.94 ± 32.94 μg/g in the liver; the value was 7.93 times higher than that of serum 5 days after treatment. The hepatic PFDoA amount was found to be 29.63% of the dose. A certain amount of PFDoA was found in the brain and adipose tissues where perfluorocarboxylic acids with less than 11 carbon atoms were sparsely distributed. The half-life of PFDoA was 55.3, 49.3, 52.4, 57.1, and 49.8 days for serum, liver, kidneys, brain, and adipose tissue, respectively. PFDoA increased hepatic levels of mRNA for Cyp4A10, Acot1, and Acox1, target genes of PPARα, suggesting that PFDoA can activate PPARα, as was observed with other PFCAs. Elevated levels of these 3 genes were observed 70 days after treatment, and the levels were less than those at 7 days. The differences between PFDoA and PFCAs with less than 11 carbon atoms were discussed. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 The Japanese Society of Toxicology |
| このアイテムを表示する：本文(pdf) |  ( 395.1KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
