ID | JOS-ijms.19877 |
著者:名前 | 秋元, 勇人/ 脇山, 春名/ 大島, 新司/ 根岸, 彰生/ 大原, 厚祐/ 沼尻, 幸彦/ 冲田, 光良/ 大嶋, 繁/ 井上, 直子/ 小林, 大介 |
著者:別形式 | Akimoto, Hayato / Wakiyama, Haruna / Oshima, Shinji / Negishi, Akio / Ohara, Kousuke / Numajiri, Sachihiko / Okita, Mitsuyoshi / Ohshima, Shigeru / Inoue, Naoko / Kobayashi, Daisuke |
著者:カナ | アキモト, ハヤト/ ワキヤマ, ハルナ/ オオシマ, シンジ/ ネギシ, アキオ/ オオハラ, コウスケ/ ヌマジリ, サチヒコ/ オキタ, ミツヨシ/ オオシマ, シゲル/ イノウエ, ナオコ/ コバヤシ, ダイスケ |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬局 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University Pharmacy / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | New South Wales |
出版者 | Ivyspring International Publisher |
NCID | AA12050919 |
電子ISSN | 14491907 |
掲載誌名 | |
巻 | 14 |
号 | 10 |
刊行年月 | 2017 |
開始ページ | 920 |
終了ページ | 926 |
コンテンツ作成日 | 2017-03-01 |
コンテンツ修正日 | 2017-05-17 |
コンテンツ登録日 | 2017-10-31 |
識別番号:DOI | info:doi/10.7150/ijms.19877 |
識別番号:DOI(リンク) | |
抄録 | Objectives: To survey time-related shifts in number of suicide-related events (SRE) during smoking cessation treatment with varenicline (VAR) in cases from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), as well as the characteristics of these shifts.Methods: We isolated cases from the FAERS database involving VAR usage where SRE was reported as an adverse event (SRE+/VAR+ case) and established a histogram of SRE+/VAR+ case numbers per week. Furthermore, we focused on “cases reporting specific adverse events prior to drug usage start” using X-bar and R chart concepts. We also attempted to exclude the influence of smoking history from the created histogram. Moreover, we constructed a histogram on central nervous system adverse events, which were frequently seen during VAR usage.Results: By removing the effects of smoking history, SRE onset signals were detected over a long period from the start of VAR use. However, expression signals for nausea and abnormal dreams were detected only in the early VAR administration period.Discussion: These results suggest that VAR use-induced SRE is expressed over a long timeframe from the start of treatment. Additionally, the period of SRE expression signal detection was longer than that of the other central nervous system adverse events (nausea and abnormal dreams). Therefore, SRE onset must be carefully monitored during smoking cessation treatment with VAR over the entire treatment period. |
キーワード | |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2017 Ivyspring International Publisher |
このアイテムを表示する:本文(pdf) | ( 720.5KB) ダウンロード回数: 回 |
このアイテムを表示する:URI | |