| ID | JOS-invivo.11099 |
| 著者：名前 | 鈴木, 龍一郎/ 坂上, 宏/ 天野, 滋/ 福地, 邦彦/ 須永, 克佳/ 金本, 大成/ 寺久保, 繁美/ 中島, 秀喜/ 白瀧, 義明/ 友村, 美根子/ 増田, 宜子/ 横瀬, 敏志/ 友村, 明人/ 渡邉, 博文/ 大川原, 正喜/ 又平, 芳春 |
| 著者：別形式 | Suzuki, Ryuichiro / Sakagami, Hiroshi / Amano, Shigeru / Fukuchi, Kunihiko / Sunaga, Katsuyoshi / Kanamoto, Taisei / Terakubo, Shigemi / Nakashima, Hideki / Shirataki, Yoshiaki / Tomomura, Mineko / Masuda, Yoshiko / Yokoe, Satoshi / Tomoura, Akito / Watanabe, Hirofumi / Masaki, Okawara / Matahira, Yoshiharu |
| 著者：カナ | スズキ, リュウイチロウ/ サカガミ, ヒロシ/ アマノ, シゲル/ フクチ, クニヒコ/ スナガ, カツヨシ/ カナモト, タイセイ/ テラクボ, シゲミ/ ナカシマ, ヒデキ/ シラタキ, ヨシアキ/ トモムラ, ミネコ/ マスダ, ヨシコ/ ヨコエ, サトシ/ トモウラ, アキト/ ワタナベ, ヒロフミ/ オオカワラ, マサキ/ マタヒラ, ヨシハル |
| 著者：所属 | 城西大学薬学部 / 明海大学歯学部 / 明海大学歯学部 / 昭和大学大学院 / 城西大学薬学部 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 聖マリアンナ医科大学 / 城西大学薬学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 明海大学歯学部 / 三生医薬株式会社 / 三生医薬株式会社 / 三生医薬株式会社 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Meikai University School of Dentistry / Meikai University School of Dentistry / Showa University, Graduate School / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / St. Marianna University School of Medicine / St. Marianna University School of Medicine / St. Marianna University School of Medicine / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Meikai University School of Dentistry / Sunsho Pharmaceutical Co. Ltd. / Sunsho Pharmaceutical Co. Ltd. / Sunsho Pharmaceutical Co. Ltd. |
| 著者版フラグ | publisher |
| 出版地 | Athens |
| 出版者 | International Institute of Anticancer Research |
| NCID | AA10714348 |
| 冊子ISSN | 0258851X |
| 電子ISSN | 17917549 |
| 掲載誌名 | |
| 巻 | 31 |
| 号 | 4 |
| 刊行年月 | 2017-07 |
| 開始ページ | 591 |
| 終了ページ | 598 |
| コンテンツ作成日 | 2017-05-10 |
| コンテンツ修正日 | 2017-06-06 |
| コンテンツ登録日 | 2018-07-26 |
| 識別番号：DOI | info:doi/10.21873/invivo.11099 |
| 識別番号：DOI（リンク） | |
| 抄録 | Background: Most previous mastic investigators have not considered its potent cytotoxicity that may significantly affect the interpretation of obtained data. In the present study, we re-evaluated several biological activities of mastic extracts, based on chemotherapeutic indexes. Materials and Methods: Pulverized mastic gum was extracted with n-hexane and then with ethyl acetate or independently with methanol or n-butanol. Tumor specificity (TS) of the extracts was determined by their cytotoxicity against human malignant and non-malignant cells. Antibacterial activity was determined by their cytotoxicity against bacteria and normal oral cells. Antiviral activity was determined by their protection of viral infection and cytotoxic activity. Cytochrome P-450 (CYP) 3A4 activity was measured by β-hydroxylation of testosterone. Results: Ethyl acetate extract showed slightly higher tumor specificity (TS=2.6) and one order higher antibacterial activity (selectivity index (SI)=0.813) than other extracts (TS=1.4-2.5; SI=0.030-0.063). All extracts showed no anti-human immunodeficiency virus (HIV) activity, but some anti-herpes simplex virus (HSV) activity, which was masked by potent cytotoxicity. They showed strong inhibitory activity against CYP3A4. Conclusion: Ethyl acetate extraction following the removal of cytotoxic and CYP3A4 inhibitory substances by n-hexane can enhance antitumor and antibacterial activity of mastic. |
| キーワード | |
| 注記 | open access journal from January 2017 / Rermission has been acquired by e-mail from publisher |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 International Institute of Anticancer Research (Dr. George J. Delinasios) |
| このアイテムを表示する：本文(pdf) |  ( 446.7KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
