城西大学機関リポジトリJURAPPARα Agonists Clofibrate and Gemfibrozil Inhibit Cell Growth, Down-Regulate hCG and Up-Regulate Progesterone Secretions in Immortalized Human Trophoblast Cell

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PPARα Agonists Clofibrate and Gemfibrozil Inhibit Cell Growth, Down-Regulate hCG and Up-Regulate Progesterone Secretions in Immortalized Human Trophoblast Cell

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ID	JOS-j.bcp.2004.03.024
著者：名前	橋本, フミ惠/Oguchi, Yoshinobu/森田, 美江子/松岡, 菊美/竹田, 省/木村, 昌行/林, 秀徳
著者：別形式	Hashimoto, Fumie / Oguchi, Yoshinobu / Morita, Mieko / Matsuoka, Kikumi / Takeda, Satoru / Kimura, Masayuki /Hayashi, Hidenori
著者：カナ	ハシモト, フミエ/Oguchi, Yoshinobu/モリタ, ミエコ/マツオカ, キクミ/タケダ, サトル/キムラ, マサユキ/ハヤシ, ヒデノリ
著者：所属	Josai University, Faculty of Pharmaceutical Sciences, Department of Pathological Biochemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pathological Biochemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pathological Biochemistry / Saitama Medical School, Saitama Medical Center, Department of Obstetrics and Gynecology / Saitama Medical School, Saitama Medical Center, Department of Obstetrics and Gynecology / Saitama Medical School, Saitama Medical Center, Department of Pharmacy / Josai University, Faculty of Pharmaceutical Sciences, Department of Pathological Biochemistry
著者：所属(別形式）	城西大学薬学部臨床生化学 / 城西大学薬学部臨床生化学 / 城西大学薬学部臨床生化学 / 埼玉医科大学総合医療センター産婦人科 / 埼玉医科大学総合医療センター産婦人科 / 埼玉医科大学総合医療センター薬剤部 / 城西大学薬学部臨床生化学
著者版フラグ	author
出版地	Amsterdam
出版者	Elsevier
NCID	AA00564486
冊子ISSN	00062952
電子ISSN	18732968
掲載誌名	Biochemical Pharmacology
巻	68
号	2
刊行年月	2017-07-15
開始ページ	313
終了ページ	321
コンテンツ作成日	2003-08-25
コンテンツ修正日	2004-03-25
コンテンツ登録日	2018-04-19
識別番号：DOI	info:doi/10.1016/j.bcp.2004.03.024
識別番号：DOI（リンク）	https://doi.org/10.1016/j.bcp.2004.03.024
PubMed番号	15194003
抄録	We studied effects of PPARα agonists clofibric acid and gemfibrozil on cell growth and functions of immortalized human extravillous trophoblast cells. Levels of DNA and protein gradually increased during incubation for 4 days. Gemfibrozil (>0.25 mM) and clofibric acid (2.5 mM) suppressed the rate of increase in DNA and protein. Specific activities of fatty acyl-CoA oxidase and catalase were increased to about 1.2–2.0 times the control value by 0.05 mM gemfibrozil and 1.0 and 2.5 mM clofibric acid after incubation for 3 days. Acid phosphatase activity showed a small increase in response to both agents, but esterase activity changed little. The secretion of progesterone from the cells into the medium was increased by 0.25 mM gemfibrozil and 1.0 and 2.5 mM clofibric acid after incubation for 3 days, but that of human chorionic gonadotropin (hCG) was decreased by 0.35 mM gemfibrozil and 2.5 mM clofibric acid. The specific activity of lactate dehydrogenase in the cells was hardly changed at all after incubation for 3 days.These results suggest that gemfibrozil and clofibric acid inhibit the proliferation of trophoblast cells. Cell metabolism is probably affected by both agents. The two agents may down-regulate hCG and up-regulate progesterone secretions.
キーワード	Gemfibrozil/Clofibric acid/Peroxisome/PPARα/Trophoblast/Progesterone
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2004 Elsevier Inc.
このアイテムを表示する：本文(pdf)	( 553.0KB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.bcp.2004.03.024

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